| Name | ARHGEF6 |
| ID | Q15052 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1-111 PROSITE-ProRule
SH3 160-219 PROSITE-ProRule
DH 241-421 PROSITE-ProRule
PH 443-548 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | ARHGEF6 | Ser684 | GSSTRKDsIPQVLLP | phosphorylation down-regulates activity | 26507661 | SIGNOR-272159 |
| PRKCQ | ARHGEF6 | Ser225 | KSSERPLsPKAVKGF | phosphorylation up-regulates activity | 25694429 | SIGNOR-272169 |
| PKA | ARHGEF6 | Ser684 | GSSTRKDsIPQVLLP | phosphorylation down-regulates activity | 26507661 | SIGNOR-272160 |
| PKC | ARHGEF6 | Ser684 | GSSTRKDsIPQVLLP | phosphorylation down-regulates activity | 26507661 | SIGNOR-272161 |
| PKA | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272163 |
| PKC | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272164 |
| PRKCQ | ARHGEF6 | Ser488 | LSASPRMsGFIYQGK | phosphorylation up-regulates activity | 25694429 | SIGNOR-272168 |
| PRKACA | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272162 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | ARHGEF6 PSer684 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272159 |
| PRKCQ | phosphorylation up-regulates → | ARHGEF6 PSer225 | phosphorylation up-regulates → | ARHGEF6 | 25694429 | SIGNOR-272169 |
| PKA | phosphorylation up-regulates → | ARHGEF6 PSer684 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272160 |
| PKC | phosphorylation up-regulates → | ARHGEF6 PSer684 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272161 |
| PKA | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272163 |
| PKC | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272164 |
| PRKCQ | phosphorylation up-regulates → | ARHGEF6 PSer488 | phosphorylation up-regulates → | ARHGEF6 | 25694429 | SIGNOR-272168 |
| PRKACA | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272162 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272159 |
| PRKCQ | phosphorylation → up-regulates activity | ARHGEF6 | SIGNOR-272169 |
| PKA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272160 |
| PKC | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272161 |
| PKA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272163 |
| PKC | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272164 |
| PRKCQ | phosphorylation → up-regulates activity | ARHGEF6 | SIGNOR-272168 |
| PRKACA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272162 |