| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272163 |
| PKC | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272164 |
| PRKACA | ARHGEF6 | Ser640 | RKTERKPsEEEYVIR | phosphorylation down-regulates activity | 26507661 | SIGNOR-272162 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272163 |
| PKC | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272164 |
| PRKACA | phosphorylation up-regulates → | ARHGEF6 PSer640 | phosphorylation down-regulates ⊣ | ARHGEF6 | 26507661 | SIGNOR-272162 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272163 |
| PKC | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272164 |
| PRKACA | phosphorylation → down-regulates activity | ARHGEF6 | SIGNOR-272162 |