| Name | PDK2 |
| ID | Q15119 |
| Role | kinase |
| Enzymatic Domains |
Histidine kinase 135-364 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 17474719 | SIGNOR-154640 |
| PDK2 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates | 7782287 | SIGNOR-33040 |
| PDK2 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 7782287 | SIGNOR-33137 |
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 7782287 | SIGNOR-33141 |
| PDK2 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109559 |
| PDK2 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109563 |
| PDK2 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 16436377 | SIGNOR-143970 |
| PDK2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 19951971 | SIGNOR-249630 |
| PDK2 | PARL | – | phosphorylation up-regulates activity | 28178523 | SIGNOR-280018 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 17474719 | SIGNOR-154640 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33040 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33137 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33141 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109559 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109563 |
| PDK2 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 16436377 | SIGNOR-143970 |
| PDK2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 19951971 | SIGNOR-249630 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-154640 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33040 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33137 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33141 |
| PDK2 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109559 |
| PDK2 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109563 |
| PDK2 | phosphorylation down-regulates | PDHA2 | SIGNOR-143970 |
| PDK2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-249630 |
| PDK2 | phosphorylation → up-regulates activity | PARL | SIGNOR-280018 |