| Name | PRKD1 |
| ID | Q15139 |
| Role | substrate |
| Enzymatic Domains |
PH 422-541 PROSITE-ProRule
Protein kinase 583-839 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | PRKD1 | Tyr502 | TTANVVYyVGENVVN | phosphorylation up-regulates activity | 12637538 | SIGNOR-247328 |
| MAPK13 | PRKD1 | – | phosphorylation down-regulates | 19135240 | SIGNOR-183280 | |
| PRKCA | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 10197446 | SIGNOR-66670 |
| ABL1 | PRKD1 | Tyr432 | KEGWMVHyTSKDTLR | phosphorylation unknown | 12637538 | SIGNOR-246211 |
| PRKCD | PRKD1 | Ser738 | ARIIGEKsFRRSVVG | phosphorylation up-regulates | 15024053 | SIGNOR-123449 |
| PRKD1 | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation unknown | 10867018 | SIGNOR-249047 |
| SRC | PRKD1 | Tyr463 | NDTGSRYyKEIPLSE | phosphorylation up-regulates activity | 12637538 | SIGNOR-247324 |
| PRKCA | PRKD1 | Ser738 | ARIIGEKsFRRSVVG | phosphorylation up-regulates | 10197446 | SIGNOR-66666 |
| PKA | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 18692497 | SIGNOR-275925 |
| PRKD1 | PRKD1 | Ser910 | KALGERVsIL | phosphorylation up-regulates | 19029298 | SIGNOR-182480 |
| PRKD1 | PRKD1 | Ser910 | KALGERVsIL | phosphorylation up-regulates | 10473617 | SIGNOR-70525 |
| PRKCH | PRKD1 | Ser738 | ARIIGEKsFRRSVVG | phosphorylation up-regulates | 10197446 | SIGNOR-66730 |
| SRC | PRKD1 | Tyr95 | KFPECGFyGMYDKIL | phosphorylation up-regulates | 17804414 | SIGNOR-157716 |
| SRC | PRKD1 | Tyr432 | KEGWMVHyTSKDTLR | phosphorylation up-regulates activity | 12637538 | SIGNOR-247320 |
| PRKD1 | PRKD1 | Ser738 | ARIIGEKsFRRSVVG | phosphorylation unknown | 10867018 | SIGNOR-249046 |
| ABL1 | PRKD1 | Tyr502 | TTANVVYyVGENVVN | phosphorylation unknown | 12637538 | SIGNOR-246215 |
| PRKCD | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 15024053 | SIGNOR-123453 |
| ABL1 | PRKD1 | Tyr463 | NDTGSRYyKEIPLSE | phosphorylation up-regulates activity | 12637538 | SIGNOR-260791 |
| ABL1 | PRKD1 | Tyr463 | NDTGSRYyKEIPLSE | phosphorylation up-regulates | 12637538 | SIGNOR-99255 |
| PRKD1 | PRKD1 | Ser205 | GVRRRRLsNVSLTGV | phosphorylation up-regulates | 10867018 | SIGNOR-78676 |
| PRKCH | PRKD1 | Ser742 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 10197446 | SIGNOR-66734 |
| ABL1 | PRKD1 | Tyr463 | NDTGSRYyKEIPLSE | phosphorylation up-regulates activity | 12637538 | SIGNOR-251430 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | PRKD1 PTyr502 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-247328 |
| PRKCA | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66670 |
| ABL1 | phosphorylation up-regulates → | PRKD1 PTyr432 | phosphorylation down-regulates ⊣ | PRKD1 | 12637538 | SIGNOR-246211 |
| PRKCD | phosphorylation up-regulates → | PRKD1 PSer738 | phosphorylation up-regulates → | PRKD1 | 15024053 | SIGNOR-123449 |
| PRKD1 | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation down-regulates ⊣ | PRKD1 | 10867018 | SIGNOR-249047 |
| SRC | phosphorylation up-regulates → | PRKD1 PTyr463 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-247324 |
| PRKCA | phosphorylation up-regulates → | PRKD1 PSer738 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66666 |
| PKA | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation up-regulates → | PRKD1 | 18692497 | SIGNOR-275925 |
| PRKD1 | phosphorylation up-regulates → | PRKD1 PSer910 | phosphorylation up-regulates → | PRKD1 | 19029298 | SIGNOR-182480 |
| PRKD1 | phosphorylation up-regulates → | PRKD1 PSer910 | phosphorylation up-regulates → | PRKD1 | 10473617 | SIGNOR-70525 |
| PRKCH | phosphorylation up-regulates → | PRKD1 PSer738 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66730 |
| SRC | phosphorylation up-regulates → | PRKD1 PTyr95 | phosphorylation up-regulates → | PRKD1 | 17804414 | SIGNOR-157716 |
| SRC | phosphorylation up-regulates → | PRKD1 PTyr432 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-247320 |
| PRKD1 | phosphorylation up-regulates → | PRKD1 PSer738 | phosphorylation down-regulates ⊣ | PRKD1 | 10867018 | SIGNOR-249046 |
| ABL1 | phosphorylation up-regulates → | PRKD1 PTyr502 | phosphorylation down-regulates ⊣ | PRKD1 | 12637538 | SIGNOR-246215 |
| PRKCD | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation up-regulates → | PRKD1 | 15024053 | SIGNOR-123453 |
| ABL1 | phosphorylation up-regulates → | PRKD1 PTyr463 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-260791 |
| ABL1 | phosphorylation up-regulates → | PRKD1 PTyr463 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-99255 |
| PRKD1 | phosphorylation up-regulates → | PRKD1 PSer205 | phosphorylation up-regulates → | PRKD1 | 10867018 | SIGNOR-78676 |
| PRKCH | phosphorylation up-regulates → | PRKD1 PSer742 | phosphorylation up-regulates → | PRKD1 | 10197446 | SIGNOR-66734 |
| ABL1 | phosphorylation up-regulates → | PRKD1 PTyr463 | phosphorylation up-regulates → | PRKD1 | 12637538 | SIGNOR-251430 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-247328 |
| MAPK13 | phosphorylation down-regulates | PRKD1 | SIGNOR-183280 |
| PRKCA | phosphorylation → up-regulates | PRKD1 | SIGNOR-66670 |
| ABL1 | phosphorylation → unknown | PRKD1 | SIGNOR-246211 |
| PRKCD | phosphorylation → up-regulates | PRKD1 | SIGNOR-123449 |
| PRKD1 | phosphorylation → unknown | PRKD1 | SIGNOR-249047 |
| SRC | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-247324 |
| PRKCA | phosphorylation → up-regulates | PRKD1 | SIGNOR-66666 |
| PKA | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-275925 |
| PRKD1 | phosphorylation → up-regulates | PRKD1 | SIGNOR-182480 |
| PRKD1 | phosphorylation → up-regulates | PRKD1 | SIGNOR-70525 |
| PRKCH | phosphorylation → up-regulates | PRKD1 | SIGNOR-66730 |
| SRC | phosphorylation → up-regulates | PRKD1 | SIGNOR-157716 |
| SRC | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-247320 |
| PRKD1 | phosphorylation → unknown | PRKD1 | SIGNOR-249046 |
| ABL1 | phosphorylation → unknown | PRKD1 | SIGNOR-246215 |
| PRKCD | phosphorylation → up-regulates | PRKD1 | SIGNOR-123453 |
| ABL1 | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-260791 |
| ABL1 | phosphorylation → up-regulates | PRKD1 | SIGNOR-99255 |
| PRKD1 | phosphorylation → up-regulates | PRKD1 | SIGNOR-78676 |
| PRKCH | phosphorylation → up-regulates | PRKD1 | SIGNOR-66734 |
| ABL1 | phosphorylation → up-regulates activity | PRKD1 | SIGNOR-251430 |