| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2R5B | KIF20A | Ser878 | RILRSRRsPLLKSGP | dephosphorylation up-regulates activity | 27939310 | SIGNOR-262660 |
| PPP2R5B | BCL2 | Ser70 | RDPVARTsPLQTPAA | dephosphorylation down-regulates | 18845789 | SIGNOR-181559 |
| PPP2R5B | AKT1 | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-252615 |
| PPP2R5B | CASP3 | Ser150 | FRGDRCRsLTGKPKL | dephosphorylation up-regulates | 15569672 | SIGNOR-131435 |
| PPP2R5B | AKT | Thr308 | KDGATMKtFCGTPEY | dephosphorylation down-regulates | 16495456 | SIGNOR-144808 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2R5B | dephosphorylation down-regulates ⊣ | KIF20A PSer878 | dephosphorylation down-regulates ⊣ | KIF20A | 27939310 | SIGNOR-262660 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | BCL2 PSer70 | dephosphorylation up-regulates → | BCL2 | 18845789 | SIGNOR-181559 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT1 PThr308 | dephosphorylation up-regulates → | AKT1 | 16495456 | SIGNOR-252615 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | CASP3 PSer150 | dephosphorylation down-regulates ⊣ | CASP3 | 15569672 | SIGNOR-131435 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | AKT PThr308 | dephosphorylation up-regulates → | AKT | 16495456 | SIGNOR-144808 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2R5B | dephosphorylation → up-regulates activity | KIF20A | SIGNOR-262660 |
| PPP2R5B | dephosphorylation down-regulates | BCL2 | SIGNOR-181559 |
| PPP2R5B | dephosphorylation down-regulates | AKT1 | SIGNOR-252615 |
| PPP2R5B | dephosphorylation → up-regulates | CASP3 | SIGNOR-131435 |
| PPP2R5B | dephosphorylation down-regulates | AKT | SIGNOR-144808 |
