| Name | PTPRR |
| ID | Q15256 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 393-647 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRR | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | dephosphorylation down-regulates activity | 11493009 | SIGNOR-248840 |
| PTPRR | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 17360477 | SIGNOR-248719 |
| PTPRR | PXN | Tyr88 | PQSSSPVyGSSAKTS | dephosphorylation down-regulates activity | 20133777 | SIGNOR-248720 |
| PTPRR | MAPK7 | Tyr221 | HQYFMTEyVATRWYR | dephosphorylation down-regulates activity | 12042304 | SIGNOR-248721 |
| PTPRR | MAPK14 | – | dephosphorylation down-regulates | 11711538 | SIGNOR-111762 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRR | dephosphorylation down-regulates ⊣ | MAPK1 PTyr187 | dephosphorylation up-regulates → | MAPK1 | 11493009 | SIGNOR-248840 |
| PTPRR | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 17360477 | SIGNOR-248719 |
| PTPRR | dephosphorylation down-regulates ⊣ | PXN PTyr88 | dephosphorylation up-regulates → | PXN | 20133777 | SIGNOR-248720 |
| PTPRR | dephosphorylation down-regulates ⊣ | MAPK7 PTyr221 | dephosphorylation up-regulates → | MAPK7 | 12042304 | SIGNOR-248721 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRR | dephosphorylation → down-regulates activity | MAPK1 | SIGNOR-248840 |
| PTPRR | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248719 |
| PTPRR | dephosphorylation → down-regulates activity | PXN | SIGNOR-248720 |
| PTPRR | dephosphorylation → down-regulates activity | MAPK7 | SIGNOR-248721 |
| PTPRR | dephosphorylation down-regulates | MAPK14 | SIGNOR-111762 |