Entity Details

Name PTPRR
ID Q15256
Role substrate
Enzymatic Domains
Tyrosine-protein phosphatase 393-647
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK3PTPRRThr361EPFVSIPtPREKVAMphosphorylation
up-regulates activity		11493009SIGNOR-249477
ERK1/2PTPRR–phosphorylation
up-regulates activity		11493009SIGNOR-270147
GbetaPTPRR–phosphorylation
up-regulates activity		11493009SIGNOR-270021
PRKACAPTPRRSer339GLQERRGsNVSLTLDphosphorylation
down-regulates activity		10601328SIGNOR-250038
MAPK1PTPRRThr361EPFVSIPtPREKVAMphosphorylation
up-regulates activity		11493009SIGNOR-249438
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK3phosphorylation
up-regulates
→
PTPRR
PThr361		phosphorylation
up-regulates
→		PTPRR11493009SIGNOR-249477
PRKACAphosphorylation
up-regulates
→
PTPRR
PSer339		phosphorylation
down-regulates
⊣		PTPRR10601328SIGNOR-250038
MAPK1phosphorylation
up-regulates
→
PTPRR
PThr361		phosphorylation
up-regulates
→		PTPRR11493009SIGNOR-249438
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK3phosphorylation
→
up-regulates activity 		PTPRRSIGNOR-249477
ERK1/2phosphorylation
→
up-regulates activity 		PTPRRSIGNOR-270147
Gbetaphosphorylation
→
up-regulates activity 		PTPRRSIGNOR-270021
PRKACAphosphorylation
→
down-regulates activity 		PTPRRSIGNOR-250038
MAPK1phosphorylation
→
up-regulates activity 		PTPRRSIGNOR-249438