| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | IRF4 | – | phosphorylation up-regulates activity | 23804646 | SIGNOR-279287 | |
| ROCK2 | IRF4 | Ser447 | YHRSIRHsSIQE | phosphorylation up-regulates | 20697158 | SIGNOR-167467 |
| ROCK2 | IRF4 | Ser448 | HRSIRHSsIQE | phosphorylation up-regulates | 20697158 | SIGNOR-167471 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK2 | phosphorylation up-regulates → | IRF4 PSer447 | phosphorylation up-regulates → | IRF4 | 20697158 | SIGNOR-167467 |
| ROCK2 | phosphorylation up-regulates → | IRF4 PSer448 | phosphorylation up-regulates → | IRF4 | 20697158 | SIGNOR-167471 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | IRF4 | SIGNOR-279287 |
| ROCK2 | phosphorylation → up-regulates | IRF4 | SIGNOR-167467 |
| ROCK2 | phosphorylation → up-regulates | IRF4 | SIGNOR-167471 |
