| Name | RPS6KA2 |
| ID | Q15349 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 1 59-318 PROSITE-ProRule
AGC-kinase C-terminal 319-388 PROSITE-ProRule
Protein kinase 2 415-672 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA2 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation down-regulates activity | 11883936 | SIGNOR-249429 |
| RPS6KA2 | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates | 20385620 | SIGNOR-164790 |
| RPS6KA2 | L1CAM | Ser1152 | RSKGGKYsVKDKEDT | phosphorylation up-regulates activity | 8663493 | SIGNOR-248949 |
| RPS6KA2 | MRE11 | Ser676 | TSSSKIMsQSQVSKG | phosphorylation down-regulates activity | 24297933 | SIGNOR-280116 |
| RPS6KA2 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates | 19282669 | SIGNOR-184591 |
| RPS6KA2 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 10837486 | SIGNOR-249044 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA2 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 11883936 | SIGNOR-249429 |
| RPS6KA2 | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 20385620 | SIGNOR-164790 |
| RPS6KA2 | phosphorylation up-regulates → | L1CAM PSer1152 | phosphorylation up-regulates → | L1CAM | 8663493 | SIGNOR-248949 |
| RPS6KA2 | phosphorylation up-regulates → | MRE11 PSer676 | phosphorylation down-regulates ⊣ | MRE11 | 24297933 | SIGNOR-280116 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 19282669 | SIGNOR-184591 |
| RPS6KA2 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 10837486 | SIGNOR-249044 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA2 | phosphorylation → down-regulates activity | NR4A1 | SIGNOR-249429 |
| RPS6KA2 | phosphorylation down-regulates | NFKBIA | SIGNOR-164790 |
| RPS6KA2 | phosphorylation → up-regulates activity | L1CAM | SIGNOR-248949 |
| RPS6KA2 | phosphorylation → down-regulates activity | MRE11 | SIGNOR-280116 |
| RPS6KA2 | phosphorylation down-regulates | BAD | SIGNOR-184591 |
| RPS6KA2 | phosphorylation → down-regulates activity | BAD | SIGNOR-249044 |