Entity Details

Name	MED1
ID	Q15648
Role	substrate
Enzymatic Domains
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
Gbeta	MED1	–		phosphorylation up-regulates	12356758	SIGNOR-270106
ERK1/2	MED1	–		phosphorylation up-regulates	12356758	SIGNOR-270199
MAPK3	MED1	Thr1032 View in OncoXplorer	SSSNRPFtPPTSTGG	phosphorylation up-regulates	12356758	SIGNOR-93989
MAPK3	MED1	Thr1457	HSKSPAYtPQNLDSE	phosphorylation up-regulates	12356758	SIGNOR-93993
MAPK1	MED1	Thr1032 View in OncoXplorer	SSSNRPFtPPTSTGG	phosphorylation up-regulates	16314496	SIGNOR-142458
MAPK1	MED1	Thr1457	HSKSPAYtPQNLDSE	phosphorylation up-regulates	16314496	SIGNOR-142462

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK3	phosphorylation up-regulates →	MED1 PThr1032	phosphorylation up-regulates →	MED1	12356758	SIGNOR-93989
MAPK3	phosphorylation up-regulates →	MED1 PThr1457	phosphorylation up-regulates →	MED1	12356758	SIGNOR-93993
MAPK1	phosphorylation up-regulates →	MED1 PThr1032	phosphorylation up-regulates →	MED1	16314496	SIGNOR-142458
MAPK1	phosphorylation up-regulates →	MED1 PThr1457	phosphorylation up-regulates →	MED1	16314496	SIGNOR-142462

Regulator	Mechanism/Effect	Target	SIGNOR-ID
Gbeta	phosphorylation → up-regulates	MED1	SIGNOR-270106
ERK1/2	phosphorylation → up-regulates	MED1	SIGNOR-270199
MAPK3	phosphorylation → up-regulates	MED1	SIGNOR-93989
MAPK3	phosphorylation → up-regulates	MED1	SIGNOR-93993
MAPK1	phosphorylation → up-regulates	MED1	SIGNOR-142458
MAPK1	phosphorylation → up-regulates	MED1	SIGNOR-142462