| Name | TWIST1 |
| ID | Q15672 |
| Role | substrate |
| Enzymatic Domains |
bHLH 108-159 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | TWIST1 | Thr121 | NVRERQRtQSLNEAF | phosphorylation down-regulates activity | 23375009 | SIGNOR-278404 |
| AKT1 | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates | 20400976 | SIGNOR-164884 |
| MAPK1 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173401 |
| MAPK8 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173417 |
| PRKCA | TWIST1 | Ser144 | TLPSDKLsKIQTLKL | phosphorylation up-regulates quantity by stabilization | 30733340 | SIGNOR-277429 |
| CSNK2A1 | TWIST1 | Ser20 | ADDSLSNsEEEPDRQ | phosphorylation up-regulates | 21559372 | SIGNOR-173672 |
| CTDSP1 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | dephosphorylation down-regulates activity | 26975371 | SIGNOR-245962 |
| MAPK14 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173409 |
| AKT | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates | 20400976 | SIGNOR-244373 |
| ERK1/2 | TWIST1 | – | phosphorylation up-regulates | 21502402 | SIGNOR-270209 | |
| MAPK3 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173413 |
| Gbeta | TWIST1 | – | phosphorylation up-regulates | 21502402 | SIGNOR-270122 | |
| IKBKB | TWIST1 | Ser123 | RERQRTQsLNEAFAA | phosphorylation down-regulates activity | 23375009 | SIGNOR-278405 |
| LIMK2 | TWIST1 | – | phosphorylation up-regulates quantity | 30716360 | SIGNOR-278952 | |
| AKT2 | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates activity | 26759241 | SIGNOR-279137 |
| MAPK11 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173405 |
| CSNK2A1 | TWIST1 | Ser18 | SPADDSLsNSEEEPD | phosphorylation up-regulates | 21559372 | SIGNOR-173668 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | TWIST1 PThr121 | phosphorylation down-regulates ⊣ | TWIST1 | 23375009 | SIGNOR-278404 |
| AKT1 | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 20400976 | SIGNOR-164884 |
| MAPK1 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173401 |
| MAPK8 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173417 |
| PRKCA | phosphorylation up-regulates → | TWIST1 PSer144 | phosphorylation up-regulates → | TWIST1 | 30733340 | SIGNOR-277429 |
| CSNK2A1 | phosphorylation up-regulates → | TWIST1 PSer20 | phosphorylation up-regulates → | TWIST1 | 21559372 | SIGNOR-173672 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | TWIST1 PSer68 | dephosphorylation up-regulates → | TWIST1 | 26975371 | SIGNOR-245962 |
| MAPK14 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173409 |
| AKT | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 20400976 | SIGNOR-244373 |
| MAPK3 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173413 |
| IKBKB | phosphorylation up-regulates → | TWIST1 PSer123 | phosphorylation down-regulates ⊣ | TWIST1 | 23375009 | SIGNOR-278405 |
| AKT2 | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 26759241 | SIGNOR-279137 |
| MAPK11 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173405 |
| CSNK2A1 | phosphorylation up-regulates → | TWIST1 PSer18 | phosphorylation up-regulates → | TWIST1 | 21559372 | SIGNOR-173668 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | TWIST1 | SIGNOR-278404 |
| AKT1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-164884 |
| MAPK1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173401 |
| MAPK8 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173417 |
| PRKCA | phosphorylation → up-regulates quantity by stabilization | TWIST1 | SIGNOR-277429 |
| CSNK2A1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173672 |
| CTDSP1 | dephosphorylation → down-regulates activity | TWIST1 | SIGNOR-245962 |
| MAPK14 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173409 |
| AKT | phosphorylation → up-regulates | TWIST1 | SIGNOR-244373 |
| ERK1/2 | phosphorylation → up-regulates | TWIST1 | SIGNOR-270209 |
| MAPK3 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173413 |
| Gbeta | phosphorylation → up-regulates | TWIST1 | SIGNOR-270122 |
| IKBKB | phosphorylation → down-regulates activity | TWIST1 | SIGNOR-278405 |
| LIMK2 | phosphorylation → up-regulates quantity | TWIST1 | SIGNOR-278952 |
| AKT2 | phosphorylation → up-regulates activity | TWIST1 | SIGNOR-279137 |
| MAPK11 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173405 |
| CSNK2A1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173668 |