| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates | 20400976 | SIGNOR-164884 |
| AKT2 | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates activity | 26759241 | SIGNOR-279137 |
| AKT | TWIST1 | Ser42 | GGRKRRSsRRSAGGG | phosphorylation up-regulates | 20400976 | SIGNOR-244373 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 20400976 | SIGNOR-164884 |
| AKT2 | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 26759241 | SIGNOR-279137 |
| AKT | phosphorylation up-regulates → | TWIST1 PSer42 | phosphorylation up-regulates → | TWIST1 | 20400976 | SIGNOR-244373 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-164884 |
| AKT2 | phosphorylation → up-regulates activity | TWIST1 | SIGNOR-279137 |
| AKT | phosphorylation → up-regulates | TWIST1 | SIGNOR-244373 |
