| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173417 |
| CTDSP1 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | dephosphorylation down-regulates activity | 26975371 | SIGNOR-245962 |
| MAPK14 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173409 |
| MAPK3 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173413 |
| MAPK11 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173405 |
| MAPK1 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173401 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173417 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | TWIST1 PSer68 | dephosphorylation up-regulates → | TWIST1 | 26975371 | SIGNOR-245962 |
| MAPK14 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173409 |
| MAPK3 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173413 |
| MAPK11 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173405 |
| MAPK1 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173401 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173417 |
| CTDSP1 | dephosphorylation → down-regulates activity | TWIST1 | SIGNOR-245962 |
| MAPK14 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173409 |
| MAPK3 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173413 |
| MAPK11 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173405 |
| MAPK1 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173401 |
