Entity Details

Name MYLK
ID Q15746
Role kinase
Enzymatic Domains
Ig-like C2-type 1 33-122
Ig-like C2-type 2 161-249
Ig-like C2-type 3 414-503
Ig-like C2-type 4 514-599
Ig-like C2-type 5 620-711
Ig-like C2-type 6 721-821
Ig-like C2-type 7 1098-1186
Ig-like C2-type 8 1238-1326
Fibronectin type-III 1334-1426
PROSITE-ProRule
Protein kinase 1464-1719
PROSITE-ProRule
Ig-like C2-type 9 1809-1898
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MYLKMYL2–phosphorylation
up-regulates activity		18166657SIGNOR-279233
MYLKMYL6B–phosphorylation
up-regulates		10092231SIGNOR-65865
MYLKMYL9Ser20KRPQRATsNVFAMFDphosphorylation
up-regulates		19851336SIGNOR-188797
MYLKMYL9Thr19KKRPQRAtSNVFAMFphosphorylation
up-regulates		19851336SIGNOR-188801
MYLKCALD1Ser744GLKVGVSsRINEWLTphosphorylation
down-regulates		20536391SIGNOR-166049
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MYLKphosphorylation
up-regulates
→
MYL9
PSer20		phosphorylation
up-regulates
→		MYL919851336SIGNOR-188797
MYLKphosphorylation
up-regulates
→
MYL9
PThr19		phosphorylation
up-regulates
→		MYL919851336SIGNOR-188801
MYLKphosphorylation
up-regulates
→
CALD1
PSer744		phosphorylation
down-regulates
⊣		CALD120536391SIGNOR-166049
Regulator Mechanism/Effect Target SIGNOR-ID
MYLKphosphorylation
→
up-regulates activity 		MYL2SIGNOR-279233
MYLKphosphorylation
→
up-regulates 		MYL6BSIGNOR-65865
MYLKphosphorylation
→
up-regulates 		MYL9SIGNOR-188797
MYLKphosphorylation
→
up-regulates 		MYL9SIGNOR-188801
MYLKphosphorylation
img/direct_inhibition.png
down-regulates 		CALD1SIGNOR-166049