Entity Details

Name MYLK
ID Q15746
Role substrate
Enzymatic Domains
Ig-like C2-type 1 33-122
Ig-like C2-type 2 161-249
Ig-like C2-type 3 414-503
Ig-like C2-type 4 514-599
Ig-like C2-type 5 620-711
Ig-like C2-type 6 721-821
Ig-like C2-type 7 1098-1186
Ig-like C2-type 8 1238-1326
Fibronectin type-III 1334-1426
PROSITE-ProRule
Protein kinase 1464-1719
PROSITE-ProRule
Ig-like C2-type 9 1809-1898
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ABL1MYLKTyr846DGGGSDRyGSLRPGWphosphorylation
up-regulates		20861316SIGNOR-168001
ABL1MYLKTyr556LNGQPIQyARSTCEAphosphorylation
up-regulates		20861316SIGNOR-167997
ABL1MYLKTyr464QEGSIEVyEDAGSHYphosphorylation
up-regulates		20861316SIGNOR-167993
SRCMYLKTyr464QEGSIEVyEDAGSHYphosphorylation
up-regulates		11113114SIGNOR-85005
PAK1MYLK–phosphorylation
down-regulates activity		10092231SIGNOR-250317
SRCMYLKTyr471YEDAGSHyLCLLKARphosphorylation
up-regulates		12408982SIGNOR-95242
SRCMYLKTyr471YEDAGSHyLCLLKARphosphorylation
up-regulates		11113114SIGNOR-85009
ABL1MYLKTyr231NQDDVGVyTCLVVNGphosphorylation
up-regulates		20861316SIGNOR-167989
PAK2MYLKSer1760
View in OncoXplorer
RAIGRLSsMAMISGLphosphorylation
down-regulates activity		10748018SIGNOR-250223
CAMK2GMYLKSer1760
View in OncoXplorer
RAIGRLSsMAMISGLphosphorylation
down-regulates activity		2160950SIGNOR-250700
PAKMYLK–phosphorylation
down-regulates activity		10748018SIGNOR-269973
MAPK1MYLK–phosphorylation
up-regulates activity		24116218SIGNOR-279226
PAK2MYLKSer1208
View in OncoXplorer
MKSRRPKsSLPPVLGphosphorylation
down-regulates activity		10748018SIGNOR-250222
SRCMYLKTyr464QEGSIEVyEDAGSHYphosphorylation
up-regulates		12408982SIGNOR-95238
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ABL1phosphorylation
up-regulates
→
MYLK
PTyr846		phosphorylation
up-regulates
→		MYLK20861316SIGNOR-168001
ABL1phosphorylation
up-regulates
→
MYLK
PTyr556		phosphorylation
up-regulates
→		MYLK20861316SIGNOR-167997
ABL1phosphorylation
up-regulates
→
MYLK
PTyr464		phosphorylation
up-regulates
→		MYLK20861316SIGNOR-167993
SRCphosphorylation
up-regulates
→
MYLK
PTyr464		phosphorylation
up-regulates
→		MYLK11113114SIGNOR-85005
SRCphosphorylation
up-regulates
→
MYLK
PTyr471		phosphorylation
up-regulates
→		MYLK12408982SIGNOR-95242
SRCphosphorylation
up-regulates
→
MYLK
PTyr471		phosphorylation
up-regulates
→		MYLK11113114SIGNOR-85009
ABL1phosphorylation
up-regulates
→
MYLK
PTyr231		phosphorylation
up-regulates
→		MYLK20861316SIGNOR-167989
PAK2phosphorylation
up-regulates
→
MYLK
PSer1760		phosphorylation
down-regulates
⊣		MYLK10748018SIGNOR-250223
CAMK2Gphosphorylation
up-regulates
→
MYLK
PSer1760		phosphorylation
down-regulates
⊣		MYLK2160950SIGNOR-250700
PAK2phosphorylation
up-regulates
→
MYLK
PSer1208		phosphorylation
down-regulates
⊣		MYLK10748018SIGNOR-250222
SRCphosphorylation
up-regulates
→
MYLK
PTyr464		phosphorylation
up-regulates
→		MYLK12408982SIGNOR-95238
Regulator Mechanism/Effect Target SIGNOR-ID
ABL1phosphorylation
→
up-regulates 		MYLKSIGNOR-168001
ABL1phosphorylation
→
up-regulates 		MYLKSIGNOR-167997
ABL1phosphorylation
→
up-regulates 		MYLKSIGNOR-167993
SRCphosphorylation
→
up-regulates 		MYLKSIGNOR-85005
PAK1phosphorylation
→
down-regulates activity 		MYLKSIGNOR-250317
SRCphosphorylation
→
up-regulates 		MYLKSIGNOR-95242
SRCphosphorylation
→
up-regulates 		MYLKSIGNOR-85009
ABL1phosphorylation
→
up-regulates 		MYLKSIGNOR-167989
PAK2phosphorylation
→
down-regulates activity 		MYLKSIGNOR-250223
CAMK2Gphosphorylation
→
down-regulates activity 		MYLKSIGNOR-250700
PAKphosphorylation
→
down-regulates activity 		MYLKSIGNOR-269973
MAPK1phosphorylation
→
up-regulates activity 		MYLKSIGNOR-279226
PAK2phosphorylation
→
down-regulates activity 		MYLKSIGNOR-250222
SRCphosphorylation
→
up-regulates 		MYLKSIGNOR-95238