| Name | TAB1 |
| ID | Q15750 |
| Role | substrate |
| Enzymatic Domains |
PPM-type phosphatase 28-365 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | TAB1 | Ser452 | STNTHTQsSSSSSDG | phosphorylation up-regulates activity | 22216226 | SIGNOR-276364 |
| MAP3K7 | TAB1 | Ser457 | TQSSSSSsDGGLFRS | phosphorylation up-regulates activity | 22216226 | SIGNOR-276367 |
| MAP3K7 | TAB1 | Ser456 | HTQSSSSsSDGGLFR | phosphorylation up-regulates activity | 22216226 | SIGNOR-276365 |
| MAPK14 | TAB1 | Ser438 | TPTLTNQsPTLTLQS | phosphorylation down-regulates activity | 14592977 | SIGNOR-118922 |
| MAP3K7 | TAB1 | Ser453 | TNTHTQSsSSSSDGG | phosphorylation up-regulates activity | 22216226 | SIGNOR-276366 |
| MAPK14 | TAB1 | Ser423 | QMVNGAHsASTLDEA | phosphorylation down-regulates activity | 19393267 | SIGNOR-185580 |
| MAPK14 | TAB1 | Thr431 | ASTLDEAtPTLTNQS | phosphorylation down-regulates activity | 19393267 | SIGNOR-185584 |
| DUSP14 | TAB1 | – | dephosphorylation down-regulates activity | 24403530 | SIGNOR-277147 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer452 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276364 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer457 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276367 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer456 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276365 |
| MAPK14 | phosphorylation up-regulates → | TAB1 PSer438 | phosphorylation down-regulates ⊣ | TAB1 | 14592977 | SIGNOR-118922 |
| MAP3K7 | phosphorylation up-regulates → | TAB1 PSer453 | phosphorylation up-regulates → | TAB1 | 22216226 | SIGNOR-276366 |
| MAPK14 | phosphorylation up-regulates → | TAB1 PSer423 | phosphorylation down-regulates ⊣ | TAB1 | 19393267 | SIGNOR-185580 |
| MAPK14 | phosphorylation up-regulates → | TAB1 PThr431 | phosphorylation down-regulates ⊣ | TAB1 | 19393267 | SIGNOR-185584 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276364 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276367 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276365 |
| MAPK14 | phosphorylation → down-regulates activity | TAB1 | SIGNOR-118922 |
| MAP3K7 | phosphorylation → up-regulates activity | TAB1 | SIGNOR-276366 |
| MAPK14 | phosphorylation → down-regulates activity | TAB1 | SIGNOR-185580 |
| MAPK14 | phosphorylation → down-regulates activity | TAB1 | SIGNOR-185584 |
| DUSP14 | dephosphorylation → down-regulates activity | TAB1 | SIGNOR-277147 |