| Name | MAPK11 |
| ID | Q15759 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 24-308 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | HBP1 | Ser402 | GFSKNCGsPGSSQLS | phosphorylation up-regulates | 14612426 | SIGNOR-119134 |
| MAPK11 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 9687510 | SIGNOR-59443 |
| MAPK11 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 9687510 | SIGNOR-59447 |
| MAPK11 | RPS6KA5 | Thr700 | LSSNPLMtPDILGSS | phosphorylation up-regulates | 9687510 | SIGNOR-59451 |
| MAPK11 | PIAS2 | Ser113 | STSVTPHsPSSPVGS | phosphorylation up-regulates activity | 16713578 | SIGNOR-262946 |
| MAPK11 | PIAS2 | Ser116 | VTPHSPSsPVGSVLL | phosphorylation up-regulates activity | 16713578 | SIGNOR-262947 |
| MAPK11 | EGFR | – | phosphorylation down-regulates | 16932740 | SIGNOR-149086 | |
| MAPK11 | TP53 | – | phosphorylation up-regulates | 17254968 | SIGNOR-152843 | |
| MAPK11 | KRT8 | Ser74 | TVNQSLLsPLVLEVD | phosphorylation up-regulates | 11788583 | SIGNOR-114063 |
| MAPK11 | MAPT | – | phosphorylation down-regulates activity | 9199504 | SIGNOR-279637 | |
| MAPK11 | ATF2 | – | phosphorylation up-regulates | 10085140 | SIGNOR-65586 | |
| MAPK11 | TCF3 | Ser139 | LNSPGPLsPSGMKGT | phosphorylation up-regulates | 15719023 | SIGNOR-134190 |
| MAPK11 | CCND3 | Thr283 | QGPSQTStPTDVTAI | phosphorylation down-regulates quantity by destabilization | 15326477 | SIGNOR-280023 |
| MAPK11 | EWSR1 | Thr79 | QPPTGYTtPTAPQAY | phosphorylation unknown | 19076070 | SIGNOR-182774 |
| MAPK11 | MEF2A | – | phosphorylation up-regulates activity | 10330143 | SIGNOR-280024 | |
| MAPK11 | MEF2C | – | phosphorylation up-regulates activity | 10330143 | SIGNOR-280025 | |
| MAPK11 | TP53BP1 | Thr1609 | LGPYEAVtPLTKAAD | phosphorylation down-regulates activity | 24703952 | SIGNOR-264447 |
| MAPK11 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | phosphorylation up-regulates | 21502402 | SIGNOR-173405 |
| MAPK11 | MAPK11 | Ser243 | MEVVGTPsPEVLAKI | phosphorylation down-regulates activity | 26976637 | SIGNOR-277215 |
| MAPK11 | MAPK11 | Ser261 | HARTYIQsLPPMPQK | phosphorylation down-regulates activity | 26976637 | SIGNOR-277214 |
| MAPK11 | MAPK11 | Thr180 | RQADEEMtGYVATRW | phosphorylation up-regulates activity | 26976637 | SIGNOR-277216 |
| MAPK11 | SMAD2 | – | phosphorylation down-regulates | 20820849 | SIGNOR-167848 | |
| MAPK11 | MAPKAPK5 | Thr182 | IDQGDLMtPQFTPYY | phosphorylation up-regulates | 9628874 | SIGNOR-58131 |
| MAPK11 | RPTOR | Ser771 | SASSTLGsPENEEHI | phosphorylation unknown | 21757713 | SIGNOR-174870 |
| MAPK11 | RPTOR | Ser863 | LTQSAPAsPTNKGVH | phosphorylation unknown | 21757713 | SIGNOR-174874 |
| MAPK11 | mTORC1 | – | phosphorylation unknown | 21757713 | SIGNOR-217580 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | phosphorylation up-regulates → | HBP1 PSer402 | phosphorylation up-regulates → | HBP1 | 14612426 | SIGNOR-119134 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59443 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59447 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PThr700 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59451 |
| MAPK11 | phosphorylation up-regulates → | PIAS2 PSer113 | phosphorylation up-regulates → | PIAS2 | 16713578 | SIGNOR-262946 |
| MAPK11 | phosphorylation up-regulates → | PIAS2 PSer116 | phosphorylation up-regulates → | PIAS2 | 16713578 | SIGNOR-262947 |
| MAPK11 | phosphorylation up-regulates → | KRT8 PSer74 | phosphorylation up-regulates → | KRT8 | 11788583 | SIGNOR-114063 |
| MAPK11 | phosphorylation up-regulates → | TCF3 PSer139 | phosphorylation up-regulates → | TCF3 | 15719023 | SIGNOR-134190 |
| MAPK11 | phosphorylation up-regulates → | CCND3 PThr283 | phosphorylation down-regulates ⊣ | CCND3 | 15326477 | SIGNOR-280023 |
| MAPK11 | phosphorylation up-regulates → | EWSR1 PThr79 | phosphorylation down-regulates ⊣ | EWSR1 | 19076070 | SIGNOR-182774 |
| MAPK11 | phosphorylation up-regulates → | TP53BP1 PThr1609 | phosphorylation down-regulates ⊣ | TP53BP1 | 24703952 | SIGNOR-264447 |
| MAPK11 | phosphorylation up-regulates → | TWIST1 PSer68 | phosphorylation up-regulates → | TWIST1 | 21502402 | SIGNOR-173405 |
| MAPK11 | phosphorylation up-regulates → | MAPK11 PSer243 | phosphorylation down-regulates ⊣ | MAPK11 | 26976637 | SIGNOR-277215 |
| MAPK11 | phosphorylation up-regulates → | MAPK11 PSer261 | phosphorylation down-regulates ⊣ | MAPK11 | 26976637 | SIGNOR-277214 |
| MAPK11 | phosphorylation up-regulates → | MAPK11 PThr180 | phosphorylation up-regulates → | MAPK11 | 26976637 | SIGNOR-277216 |
| MAPK11 | phosphorylation up-regulates → | MAPKAPK5 PThr182 | phosphorylation up-regulates → | MAPKAPK5 | 9628874 | SIGNOR-58131 |
| MAPK11 | phosphorylation up-regulates → | RPTOR PSer771 | phosphorylation down-regulates ⊣ | RPTOR | 21757713 | SIGNOR-174870 |
| MAPK11 | phosphorylation up-regulates → | RPTOR PSer863 | phosphorylation down-regulates ⊣ | RPTOR | 21757713 | SIGNOR-174874 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK11 | phosphorylation → up-regulates | HBP1 | SIGNOR-119134 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59443 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59447 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59451 |
| MAPK11 | phosphorylation → up-regulates activity | PIAS2 | SIGNOR-262946 |
| MAPK11 | phosphorylation → up-regulates activity | PIAS2 | SIGNOR-262947 |
| MAPK11 | phosphorylation down-regulates | EGFR | SIGNOR-149086 |
| MAPK11 | phosphorylation → up-regulates | TP53 | SIGNOR-152843 |
| MAPK11 | phosphorylation → up-regulates | KRT8 | SIGNOR-114063 |
| MAPK11 | phosphorylation → down-regulates activity | MAPT | SIGNOR-279637 |
| MAPK11 | phosphorylation → up-regulates | ATF2 | SIGNOR-65586 |
| MAPK11 | phosphorylation → up-regulates | TCF3 | SIGNOR-134190 |
| MAPK11 | phosphorylation down-regulates quantity by destabilization | CCND3 | SIGNOR-280023 |
| MAPK11 | phosphorylation → unknown | EWSR1 | SIGNOR-182774 |
| MAPK11 | phosphorylation → up-regulates activity | MEF2A | SIGNOR-280024 |
| MAPK11 | phosphorylation → up-regulates activity | MEF2C | SIGNOR-280025 |
| MAPK11 | phosphorylation → down-regulates activity | TP53BP1 | SIGNOR-264447 |
| MAPK11 | phosphorylation → up-regulates | TWIST1 | SIGNOR-173405 |
| MAPK11 | phosphorylation → down-regulates activity | MAPK11 | SIGNOR-277215 |
| MAPK11 | phosphorylation → down-regulates activity | MAPK11 | SIGNOR-277214 |
| MAPK11 | phosphorylation → up-regulates activity | MAPK11 | SIGNOR-277216 |
| MAPK11 | phosphorylation down-regulates | SMAD2 | SIGNOR-167848 |
| MAPK11 | phosphorylation → up-regulates | MAPKAPK5 | SIGNOR-58131 |
| MAPK11 | phosphorylation → unknown | RPTOR | SIGNOR-174870 |
| MAPK11 | phosphorylation → unknown | RPTOR | SIGNOR-174874 |
| MAPK11 | phosphorylation → unknown | mTORC1 | SIGNOR-217580 |