| Name | SMAD1 |
| ID | Q15797 |
| Role | substrate |
| Enzymatic Domains |
MH1 12-136 PROSITE-ProRule
MH2 271-465 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates | 19914161 | SIGNOR-189129 |
| CDK8 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914161 | SIGNOR-189133 |
| MAPK1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates activity | 9335504 | SIGNOR-52687 |
| ACVR1 | SMAD1 | – | phosphorylation up-regulates | 9748228 | SIGNOR-60174 | |
| CTDSPL | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248313 |
| ACVR1 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 9748228 | SIGNOR-247674 |
| GSK3B | SMAD1 | – | phosphorylation down-regulates | 18045539 | SIGNOR-159484 | |
| CDK9 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161666 |
| CTDSP1 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248798 |
| CTDSP2 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248301 |
| CTDSP2 | SMAD1 | – | dephosphorylation down-regulates | 16882717 | SIGNOR-148434 | |
| BMPR1A | SMAD1 | – | phosphorylation up-regulates activity | 19620713 | SIGNOR-255263 | |
| BMPR1A | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates | 9136927 | SIGNOR-249649 |
| MAP3K7 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates activity | 19536134 | SIGNOR-279420 |
| CKM complex | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273140 |
| CTDSP2 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248303 |
| ERK1/2 | SMAD1 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270137 | |
| Gbeta | SMAD1 | – | phosphorylation down-regulates | 10197981 | SIGNOR-270005 | |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 9335504 | SIGNOR-52691 |
| CDK9 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-161573 |
| MAP4K4 | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276335 |
| MAPK1 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 9335504 | SIGNOR-52678 |
| BMPR1A/1B/2 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates activity | 9136927 | SIGNOR-217989 |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-161605 |
| CDK9 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914161 | SIGNOR-161569 |
| BMPR1A | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9136927 | SIGNOR-210084 |
| TNIK | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276334 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273148 |
| CDK8 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-189137 |
| BMPR1B | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9335504 | SIGNOR-52666 |
| CKM complex | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273145 |
| MAPK1 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914161 | SIGNOR-161597 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273143 |
| MAP3K7 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 19536134 | SIGNOR-279419 |
| CTDSPL | SMAD1 | Ser195 | PNSSYPNsPGSSSST | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248314 |
| MAPK1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates activity | 19914161 | SIGNOR-161601 |
| MAPK3 | SMAD1 | – | phosphorylation down-regulates | 10197981 | SIGNOR-66755 | |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-189141 |
| BMPR1A/1B/2 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 9136927 | SIGNOR-217985 |
| PDP2 | SMAD1 | – | dephosphorylation down-regulates | 16510868 | SIGNOR-144909 | |
| MAPK1 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates | 9335504 | SIGNOR-52674 |
| BMPR1B | SMAD1 | Ser462 | GSPHNPIsSVS | phosphorylation up-regulates | 9335504 | SIGNOR-52662 |
| BMPR1A | SMAD1 | – | phosphorylation up-regulates | 19620713 | SIGNOR-187181 | |
| MINK1 | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276336 |
| CTDSP2 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248302 |
| BMPR1B | SMAD1 | – | phosphorylation up-regulates activity | 19620713 | SIGNOR-255265 | |
| BMPR1A/1B/2 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9136927 | SIGNOR-210079 |
| CTDSPL | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248316 |
| CTDSP2 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248300 |
| CTDSP1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248801 |
| CDK8 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914168 | SIGNOR-161626 |
| CTDSP1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248800 |
| CDK9 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-161577 |
| CKM complex | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273144 |
| ATM | SMAD1 | Ser239 | DPMTQDGsQPMDTNM | phosphorylation up-regulates | 22588298 | SIGNOR-197533 |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161634 |
| CTDSP1 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248799 |
| CTDSP1 | SMAD1 | – | dephosphorylation down-regulates | 16882717 | SIGNOR-148396 | |
| PPM1A | SMAD1 | – | dephosphorylation down-regulates | 16931515 | SIGNOR-149077 | |
| CDK9 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914168 | SIGNOR-161658 |
| CKM complex | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273152 |
| BMPR1A/1B/2 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates | 9136927 | SIGNOR-249648 |
| MAPK1 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates | 19914161 | SIGNOR-161593 |
| ACVR1 | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates activity | 9748228 | SIGNOR-251439 |
| CDK9 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | phosphorylation down-regulates | 19914161 | SIGNOR-161565 |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161694 |
| MAPK1 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | phosphorylation down-regulates | 19914168 | SIGNOR-161686 |
| BMPR1B | SMAD1 | – | phosphorylation up-regulates | 19620713 | SIGNOR-187190 | |
| PDP1 | SMAD1 | – | dephosphorylation down-regulates | 16510868 | SIGNOR-144876 | |
| BMPR1B | SMAD1 | Ser465 | HNPISSVs | phosphorylation up-regulates | 9335504 | SIGNOR-52670 |
| CTDSPL | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248315 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189129 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189133 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52687 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer187 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248313 |
| ACVR1 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9748228 | SIGNOR-247674 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161666 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer187 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248798 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer195 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248301 |
| BMPR1A | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-249649 |
| MAP3K7 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 19536134 | SIGNOR-279420 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273140 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248303 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52691 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161573 |
| MAP4K4 | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276335 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52678 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-217989 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161605 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161569 |
| BMPR1A | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-210084 |
| TNIK | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276334 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273148 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189137 |
| BMPR1B | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9335504 | SIGNOR-52666 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273145 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161597 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-273143 |
| MAP3K7 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 19536134 | SIGNOR-279419 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer195 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248314 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161601 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189141 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-217985 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52674 |
| BMPR1B | phosphorylation up-regulates → | SMAD1 PSer462 | phosphorylation up-regulates → | SMAD1 | 9335504 | SIGNOR-52662 |
| MINK1 | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276336 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248302 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-210079 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248316 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer187 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248300 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248801 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161626 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248800 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161577 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273144 |
| ATM | phosphorylation up-regulates → | SMAD1 PSer239 | phosphorylation up-regulates → | SMAD1 | 22588298 | SIGNOR-197533 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161634 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer195 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248799 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161658 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-273152 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-249648 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161593 |
| ACVR1 | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9748228 | SIGNOR-251439 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer187 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161565 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161694 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer195 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161686 |
| BMPR1B | phosphorylation up-regulates → | SMAD1 PSer465 | phosphorylation up-regulates → | SMAD1 | 9335504 | SIGNOR-52670 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248315 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189129 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189133 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-52687 |
| ACVR1 | phosphorylation → up-regulates | SMAD1 | SIGNOR-60174 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248313 |
| ACVR1 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-247674 |
| GSK3B | phosphorylation down-regulates | SMAD1 | SIGNOR-159484 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161666 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248798 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248301 |
| CTDSP2 | dephosphorylation down-regulates | SMAD1 | SIGNOR-148434 |
| BMPR1A | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-255263 |
| BMPR1A | phosphorylation → up-regulates | SMAD1 | SIGNOR-249649 |
| MAP3K7 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-279420 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273140 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248303 |
| ERK1/2 | phosphorylation down-regulates | SMAD1 | SIGNOR-270137 |
| Gbeta | phosphorylation down-regulates | SMAD1 | SIGNOR-270005 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-52691 |
| CDK9 | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-161573 |
| MAP4K4 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276335 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-52678 |
| BMPR1A/1B/2 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-217989 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161605 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161569 |
| BMPR1A | phosphorylation → up-regulates | SMAD1 | SIGNOR-210084 |
| TNIK | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276334 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273148 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-189137 |
| BMPR1B | phosphorylation → up-regulates | SMAD1 | SIGNOR-52666 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273145 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161597 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273143 |
| MAP3K7 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-279419 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248314 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-161601 |
| MAPK3 | phosphorylation down-regulates | SMAD1 | SIGNOR-66755 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189141 |
| BMPR1A/1B/2 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-217985 |
| PDP2 | dephosphorylation down-regulates | SMAD1 | SIGNOR-144909 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-52674 |
| BMPR1B | phosphorylation → up-regulates | SMAD1 | SIGNOR-52662 |
| BMPR1A | phosphorylation → up-regulates | SMAD1 | SIGNOR-187181 |
| MINK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276336 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248302 |
| BMPR1B | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-255265 |
| BMPR1A/1B/2 | phosphorylation → up-regulates | SMAD1 | SIGNOR-210079 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248316 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248300 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248801 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-161626 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248800 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161577 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273144 |
| ATM | phosphorylation → up-regulates | SMAD1 | SIGNOR-197533 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-161634 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248799 |
| CTDSP1 | dephosphorylation down-regulates | SMAD1 | SIGNOR-148396 |
| PPM1A | dephosphorylation down-regulates | SMAD1 | SIGNOR-149077 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161658 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273152 |
| BMPR1A/1B/2 | phosphorylation → up-regulates | SMAD1 | SIGNOR-249648 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161593 |
| ACVR1 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-251439 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161565 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161694 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161686 |
| BMPR1B | phosphorylation → up-regulates | SMAD1 | SIGNOR-187190 |
| PDP1 | dephosphorylation down-regulates | SMAD1 | SIGNOR-144876 |
| BMPR1B | phosphorylation → up-regulates | SMAD1 | SIGNOR-52670 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248315 |