| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 19536134 | SIGNOR-279419 |
| BMPR1A/1B/2 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9136927 | SIGNOR-210079 |
| BMPR1B | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9335504 | SIGNOR-52666 |
| BMPR1A | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates | 9136927 | SIGNOR-210084 |
| ACVR1 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 9748228 | SIGNOR-247674 |
| BMPR1A/1B/2 | SMAD1 | Ser463 | SPHNPISsVS | phosphorylation up-regulates activity | 9136927 | SIGNOR-217985 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 19536134 | SIGNOR-279419 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-210079 |
| BMPR1B | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9335504 | SIGNOR-52666 |
| BMPR1A | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-210084 |
| ACVR1 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9748228 | SIGNOR-247674 |
| BMPR1A/1B/2 | phosphorylation up-regulates → | SMAD1 PSer463 | phosphorylation up-regulates → | SMAD1 | 9136927 | SIGNOR-217985 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K7 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-279419 |
| BMPR1A/1B/2 | phosphorylation → up-regulates | SMAD1 | SIGNOR-210079 |
| BMPR1B | phosphorylation → up-regulates | SMAD1 | SIGNOR-52666 |
| BMPR1A | phosphorylation → up-regulates | SMAD1 | SIGNOR-210084 |
| ACVR1 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-247674 |
| BMPR1A/1B/2 | phosphorylation → up-regulates activity | SMAD1 | SIGNOR-217985 |
