| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates activity | 9335504 | SIGNOR-52687 |
| CDK9 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-161573 |
| MAPK1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates activity | 19914161 | SIGNOR-161601 |
| CDK8 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-189137 |
| CTDSP1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248800 |
| CTDSPL | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248315 |
| CTDSP2 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248302 |
| CKM complex | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273144 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52687 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161573 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161601 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189137 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248800 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248315 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248302 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer206 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273144 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-52687 |
| CDK9 | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-161573 |
| MAPK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-161601 |
| CDK8 | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-189137 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248800 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248315 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248302 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273144 |
