| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSPL | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248316 |
| CTDSP1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248801 |
| CDK9 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-161577 |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161634 |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161694 |
| CDK9 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914168 | SIGNOR-161666 |
| CTDSP2 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248303 |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 9335504 | SIGNOR-52691 |
| MAPK1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-161605 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914161 | SIGNOR-273148 |
| CKM complex | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates quantity by destabilization | 19914168 | SIGNOR-273143 |
| CDK8 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | phosphorylation down-regulates | 19914161 | SIGNOR-189141 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248316 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248801 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161577 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161634 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161694 |
| CDK9 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-161666 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248303 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 9335504 | SIGNOR-52691 |
| MAPK1 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-161605 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-273148 |
| CKM complex | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914168 | SIGNOR-273143 |
| CDK8 | phosphorylation up-regulates → | SMAD1 PSer214 | phosphorylation down-regulates ⊣ | SMAD1 | 19914161 | SIGNOR-189141 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSPL | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248316 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248801 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161577 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-161634 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161694 |
| CDK9 | phosphorylation down-regulates | SMAD1 | SIGNOR-161666 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248303 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-52691 |
| MAPK1 | phosphorylation down-regulates | SMAD1 | SIGNOR-161605 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273148 |
| CKM complex | phosphorylation down-regulates quantity by destabilization | SMAD1 | SIGNOR-273143 |
| CDK8 | phosphorylation down-regulates | SMAD1 | SIGNOR-189141 |
