| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TNIK | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276334 |
| MINK1 | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276336 |
| MAP4K4 | SMAD1 | Thr322 | SNVNRNStIENTRRH | phosphorylation down-regulates activity | 21690388 | SIGNOR-276335 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TNIK | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276334 |
| MINK1 | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276336 |
| MAP4K4 | phosphorylation up-regulates → | SMAD1 PThr322 | phosphorylation down-regulates ⊣ | SMAD1 | 21690388 | SIGNOR-276335 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TNIK | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276334 |
| MINK1 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276336 |
| MAP4K4 | phosphorylation → down-regulates activity | SMAD1 | SIGNOR-276335 |