| Name | GRK1 |
| ID | Q15835 |
| Role | kinase |
| Enzymatic Domains |
RGS 58-175 PROSITE-ProRule
Protein kinase 190-455 PROSITE-ProRule
AGC-kinase C-terminal 456-521 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK1 | F2RL2 | – | phosphorylation down-regulates activity | 20463241 | SIGNOR-279993 | |
| GRK1 | RHO | Ser334 | PLGDDEAsATVSKTE | phosphorylation up-regulates activity | 8617805 | SIGNOR-251189 |
| GRK1 | RHO | Ser338 | DEASATVsKTETSQV | phosphorylation up-regulates activity | 8617805 | SIGNOR-251190 |
| GRK1 | RHO | Ser343 | TVSKTETsQVAPA | phosphorylation up-regulates activity | 8617805 | SIGNOR-251191 |
| GRK1 | TIAM1 | – | phosphorylation down-regulates activity | 20463241 | SIGNOR-279995 | |
| GRK1 | GRK1 | Ser21 | AFIAARGsFDGSSSQ | phosphorylation down-regulates activity | 1527025 | SIGNOR-251186 |
| GRK1 | GRK1 | Ser491 | IQDVGAFsTVKGVAF | phosphorylation down-regulates activity | 1527025 | SIGNOR-251187 |
| GRK1 | GRK1 | Thr492 | QDVGAFStVKGVAFD | phosphorylation down-regulates activity | 1527025 | SIGNOR-251188 |
| GRK1 | TIAM2 | – | phosphorylation down-regulates activity | 20463241 | SIGNOR-279997 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GRK1 | phosphorylation up-regulates → | RHO PSer334 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251189 |
| GRK1 | phosphorylation up-regulates → | RHO PSer338 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251190 |
| GRK1 | phosphorylation up-regulates → | RHO PSer343 | phosphorylation up-regulates → | RHO | 8617805 | SIGNOR-251191 |
| GRK1 | phosphorylation up-regulates → | GRK1 PSer21 | phosphorylation down-regulates ⊣ | GRK1 | 1527025 | SIGNOR-251186 |
| GRK1 | phosphorylation up-regulates → | GRK1 PSer491 | phosphorylation down-regulates ⊣ | GRK1 | 1527025 | SIGNOR-251187 |
| GRK1 | phosphorylation up-regulates → | GRK1 PThr492 | phosphorylation down-regulates ⊣ | GRK1 | 1527025 | SIGNOR-251188 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GRK1 | phosphorylation → down-regulates activity | F2RL2 | SIGNOR-279993 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251189 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251190 |
| GRK1 | phosphorylation → up-regulates activity | RHO | SIGNOR-251191 |
| GRK1 | phosphorylation → down-regulates activity | TIAM1 | SIGNOR-279995 |
| GRK1 | phosphorylation → down-regulates activity | GRK1 | SIGNOR-251186 |
| GRK1 | phosphorylation → down-regulates activity | GRK1 | SIGNOR-251187 |
| GRK1 | phosphorylation → down-regulates activity | GRK1 | SIGNOR-251188 |
| GRK1 | phosphorylation → down-regulates activity | TIAM2 | SIGNOR-279997 |