Entity Details

Name GRK1
ID Q15835
Role substrate
Enzymatic Domains
RGS 58-175
PROSITE-ProRule
Protein kinase 190-455
PROSITE-ProRule
AGC-kinase C-terminal 456-521
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity		15946941SIGNOR-274079
GRK1GRK1Thr492QDVGAFStVKGVAFDphosphorylation
down-regulates activity		1527025SIGNOR-251188
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity		15946941SIGNOR-276034
GRK1GRK1Ser491IQDVGAFsTVKGVAFphosphorylation
down-regulates activity		1527025SIGNOR-251187
PKAGRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity		15946941SIGNOR-260841
GRK1GRK1Ser21AFIAARGsFDGSSSQphosphorylation
down-regulates activity		1527025SIGNOR-251186
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PKAphosphorylation
up-regulates
→
GRK1
PSer21		phosphorylation
down-regulates
⊣		GRK115946941SIGNOR-274079
GRK1phosphorylation
up-regulates
→
GRK1
PThr492		phosphorylation
down-regulates
⊣		GRK11527025SIGNOR-251188
PKAphosphorylation
up-regulates
→
GRK1
PSer21		phosphorylation
down-regulates
⊣		GRK115946941SIGNOR-276034
GRK1phosphorylation
up-regulates
→
GRK1
PSer491		phosphorylation
down-regulates
⊣		GRK11527025SIGNOR-251187
PKAphosphorylation
up-regulates
→
GRK1
PSer21		phosphorylation
down-regulates
⊣		GRK115946941SIGNOR-260841
GRK1phosphorylation
up-regulates
→
GRK1
PSer21		phosphorylation
down-regulates
⊣		GRK11527025SIGNOR-251186
Regulator Mechanism/Effect Target SIGNOR-ID
PKAphosphorylation
→
down-regulates activity 		GRK1SIGNOR-274079
GRK1phosphorylation
→
down-regulates activity 		GRK1SIGNOR-251188
PKAphosphorylation
→
down-regulates activity 		GRK1SIGNOR-276034
GRK1phosphorylation
→
down-regulates activity 		GRK1SIGNOR-251187
PKAphosphorylation
→
down-regulates activity 		GRK1SIGNOR-260841
GRK1phosphorylation
→
down-regulates activity 		GRK1SIGNOR-251186