| Name | ZYX |
| ID | Q15942 |
| Role | substrate |
| Enzymatic Domains |
LIM zinc-binding 1 384-443 PROSITE-ProRule
LIM zinc-binding 2 444-503 PROSITE-ProRule
LIM zinc-binding 3 504-570 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | ZYX | Ser142 | PQPREKVsSIDLEID | phosphorylation down-regulates | 17572661 | SIGNOR-156122 |
| AKT | ZYX | Ser142 | PQPREKVsSIDLEID | phosphorylation down-regulates | 17572661 | SIGNOR-244389 |
| CDK1 | ZYX | – | phosphorylation up-regulates activity | 10831611 | SIGNOR-279498 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | ZYX PSer142 | phosphorylation down-regulates ⊣ | ZYX | 17572661 | SIGNOR-156122 |
| AKT | phosphorylation up-regulates → | ZYX PSer142 | phosphorylation down-regulates ⊣ | ZYX | 17572661 | SIGNOR-244389 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation down-regulates | ZYX | SIGNOR-156122 |
| AKT | phosphorylation down-regulates | ZYX | SIGNOR-244389 |
| CDK1 | phosphorylation → up-regulates activity | ZYX | SIGNOR-279498 |