| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK2 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-189049 |
| CHEK1 | SNCB | Tyr127 | EDPPQEEyQEYEPEA | phosphorylation unknown | 21699177 | SIGNOR-174590 |
| PLK3 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-189057 |
| PLK1 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-176079 |
| GRK5 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 10852916 | SIGNOR-251203 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK2 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-189049 |
| CHEK1 | phosphorylation up-regulates → | SNCB PTyr127 | phosphorylation down-regulates ⊣ | SNCB | 21699177 | SIGNOR-174590 |
| PLK3 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-189057 |
| PLK1 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-176079 |
| GRK5 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 10852916 | SIGNOR-251203 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK2 | phosphorylation → down-regulates activity | SNCB | SIGNOR-189049 |
| CHEK1 | phosphorylation → unknown | SNCB | SIGNOR-174590 |
| PLK3 | phosphorylation → down-regulates activity | SNCB | SIGNOR-189057 |
| PLK1 | phosphorylation → down-regulates activity | SNCB | SIGNOR-176079 |
| GRK5 | phosphorylation → down-regulates activity | SNCB | SIGNOR-251203 |
