| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | CCDC6 | Ser244 | QPVSAPPsPRDISME | phosphorylation up-regulates | 14712216 | SIGNOR-121198 |
| MAPK3 | CCDC6 | Ser244 | QPVSAPPsPRDISME | phosphorylation up-regulates activity | 14712216 | SIGNOR-276003 |
| ATM | CCDC6 | Thr434 | TPPPSPNtQTPVQPP | phosphorylation up-regulates | 23108047 | SIGNOR-199276 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | CCDC6 PSer244 | phosphorylation up-regulates → | CCDC6 | 14712216 | SIGNOR-121198 |
| MAPK3 | phosphorylation up-regulates → | CCDC6 PSer244 | phosphorylation up-regulates → | CCDC6 | 14712216 | SIGNOR-276003 |
| ATM | phosphorylation up-regulates → | CCDC6 PThr434 | phosphorylation up-regulates → | CCDC6 | 23108047 | SIGNOR-199276 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates | CCDC6 | SIGNOR-121198 |
| MAPK3 | phosphorylation → up-regulates activity | CCDC6 | SIGNOR-276003 |
| ATM | phosphorylation → up-regulates | CCDC6 | SIGNOR-199276 |
