Entity Details

Name NFE2L2
ID Q16236
Role substrate
Enzymatic Domains
bZIP 497-560
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCBNFE2L2Ser40SREVFDFsQRRKEYEphosphorylation
up-regulates		12198130SIGNOR-91830
PRKAA1NFE2L2Ser374GDTLLGLsDSEVEELphosphorylation
up-regulates activity		31805502SIGNOR-277494
PRKAA1NFE2L2Ser433
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PEKELPVsPGHRKTPphosphorylation
up-regulates activity		31805502SIGNOR-277495
PRKAA1NFE2L2Ser408GDMVQPLsPSQGQSTphosphorylation
up-regulates activity		31805502SIGNOR-277496
FYNNFE2L2Tyr576RDEDGKPySPSEYSLphosphorylation
down-regulates quantity		23434765SIGNOR-278358
PRKCDNFE2L2Ser40SREVFDFsQRRKEYEphosphorylation
up-regulates activity		12198130SIGNOR-249161
PRKCANFE2L2Ser40SREVFDFsQRRKEYEphosphorylation
up-regulates		12198130SIGNOR-91826
PAK4NFE2L2Thr369ESSSYGDtLLGLSDSphosphorylation
down-regulates quantity by destabilization		35108418SIGNOR-277583
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCBphosphorylation
up-regulates
→
NFE2L2
PSer40		phosphorylation
up-regulates
→		NFE2L212198130SIGNOR-91830
PRKAA1phosphorylation
up-regulates
→
NFE2L2
PSer374		phosphorylation
up-regulates
→		NFE2L231805502SIGNOR-277494
PRKAA1phosphorylation
up-regulates
→
NFE2L2
PSer433		phosphorylation
up-regulates
→		NFE2L231805502SIGNOR-277495
PRKAA1phosphorylation
up-regulates
→
NFE2L2
PSer408		phosphorylation
up-regulates
→		NFE2L231805502SIGNOR-277496
FYNphosphorylation
up-regulates
→
NFE2L2
PTyr576		phosphorylation
down-regulates
⊣		NFE2L223434765SIGNOR-278358
PRKCDphosphorylation
up-regulates
→
NFE2L2
PSer40		phosphorylation
up-regulates
→		NFE2L212198130SIGNOR-249161
PRKCAphosphorylation
up-regulates
→
NFE2L2
PSer40		phosphorylation
up-regulates
→		NFE2L212198130SIGNOR-91826
PAK4phosphorylation
up-regulates
→
NFE2L2
PThr369		phosphorylation
down-regulates
⊣		NFE2L235108418SIGNOR-277583
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCBphosphorylation
→
up-regulates 		NFE2L2SIGNOR-91830
PRKAA1phosphorylation
→
up-regulates activity 		NFE2L2SIGNOR-277494
PRKAA1phosphorylation
→
up-regulates activity 		NFE2L2SIGNOR-277495
PRKAA1phosphorylation
→
up-regulates activity 		NFE2L2SIGNOR-277496
FYNphosphorylation
→
down-regulates quantity 		NFE2L2SIGNOR-278358
PRKCDphosphorylation
→
up-regulates activity 		NFE2L2SIGNOR-249161
PRKCAphosphorylation
→
up-regulates 		NFE2L2SIGNOR-91826
PAK4phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NFE2L2SIGNOR-277583