| Name | PKN1 |
| ID | Q16512 |
| Role | kinase |
| Enzymatic Domains |
REM-1 1 25-100 PROSITE-ProRule
REM-1 2 112-193 PROSITE-ProRule
REM-1 3 201-280 PROSITE-ProRule
C2 307-470 PROSITE-ProRule
Protein kinase 615-874 PROSITE-ProRule
AGC-kinase C-terminal 875-942 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | MEFV | Ser208 | VRLRRNAsSAGRLQG | phosphorylation down-regulates activity | 27270401 | SIGNOR-275462 |
| PKN1 | MEFV | Ser242 | SGKMRPRsLEVTIST | phosphorylation down-regulates activity | 27270401 | SIGNOR-275461 |
| PKN1 | SNAI1 | Ser246 | QACARTFsRMSLLHK | phosphorylation up-regulates | 15833848 | SIGNOR-135609 |
| PKN1 | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation down-regulates activity | 21749319 | SIGNOR-174755 |
| PKN1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 11733498 | SIGNOR-112549 |
| PKN1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates | 15849194 | SIGNOR-135679 |
| PKN1 | AR | – | phosphorylation up-regulates | 17251915 | SIGNOR-152762 | |
| PKN1 | MAPT | Ser637 | VDLSKVTsKCGSLGN | phosphorylation down-regulates | 11104762 | SIGNOR-84958 |
| PKN1 | PGAM1 | Ser118 | QVKIWRRsYDVPPPP | phosphorylation down-regulates | 12189148 | SIGNOR-91602 |
| PKN1 | PGAM1 | Ser23 | WNLENRFsGWYDADL | phosphorylation down-regulates | 12189148 | SIGNOR-91606 |
| PKN1 | MARCKS | Ser159 | KKKKKRFsFKKSFKL | phosphorylation down-regulates activity | 8557118 | SIGNOR-243199 |
| PKN1 | MARCKS | Ser163 | KRFSFKKsFKLSGFS | phosphorylation down-regulates activity | 8557118 | SIGNOR-249651 |
| PKN1 | MARCKS | Ser170 | SFKLSGFsFKKNKKE | phosphorylation down-regulates activity | 8557118 | SIGNOR-249671 |
| PKN1 | MARCKS | Ser159 | KKKKKRFsFKKSFKL | phosphorylation unknown | 8557118 | SIGNOR-248937 |
| PKN1 | MARCKS | Ser163 | KRFSFKKsFKLSGFS | phosphorylation unknown | 8557118 | SIGNOR-248938 |
| PKN1 | MARCKS | Ser170 | SFKLSGFsFKKNKKE | phosphorylation unknown | 8557118 | SIGNOR-248939 |
| PKN1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 15791647 | SIGNOR-249277 |
| PKN1 | PGM1 | Thr467 | SANDKVYtVEKADNF | phosphorylation up-regulates | 15378030 | SIGNOR-128722 |
| PKN1 | FOXO1 | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates | 12560069 | SIGNOR-97882 |
| PKN1 | PKN1 | Ser374 | GLYSRSGsLSGRSSL | phosphorylation up-regulates activity | 10467162 | SIGNOR-249021 |
| PKN1 | PKN1 | Thr531 | PNATGTGtFSPGASP | phosphorylation up-regulates activity | 10467162 | SIGNOR-249020 |
| PKN1 | PKN1 | Thr64 | ENLRRATtDLGRSLG | phosphorylation up-regulates activity | 10467162 | SIGNOR-249019 |
| PKN1 | MAPK14 | – | phosphorylation up-regulates | 17251915 | SIGNOR-152765 | |
| PKN1 | ARHGEF2 | Ser886 | PVDPRRRsLPAGDAL | phosphorylation down-regulates | 14970201 | SIGNOR-122191 |
| PKN1 | MRTFA | – | phosphorylation down-regulates activity | 31564129 | SIGNOR-280067 | |
| PKN1 | MAP3K20 | – | phosphorylation up-regulates | 17251915 | SIGNOR-152768 | |
| PKN1 | FOXO | Ser256 | SPRRRAAsMDNNSKF | phosphorylation down-regulates | 12560069 | SIGNOR-252968 |
| PKN1 | PGAM | – | phosphorylation down-regulates | 12189148 | SIGNOR-270282 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKN1 | phosphorylation up-regulates → | MEFV PSer208 | phosphorylation down-regulates ⊣ | MEFV | 27270401 | SIGNOR-275462 |
| PKN1 | phosphorylation up-regulates → | MEFV PSer242 | phosphorylation down-regulates ⊣ | MEFV | 27270401 | SIGNOR-275461 |
| PKN1 | phosphorylation up-regulates → | SNAI1 PSer246 | phosphorylation up-regulates → | SNAI1 | 15833848 | SIGNOR-135609 |
| PKN1 | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation down-regulates ⊣ | EGFR | 21749319 | SIGNOR-174755 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 11733498 | SIGNOR-112549 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 15849194 | SIGNOR-135679 |
| PKN1 | phosphorylation up-regulates → | MAPT PSer637 | phosphorylation down-regulates ⊣ | MAPT | 11104762 | SIGNOR-84958 |
| PKN1 | phosphorylation up-regulates → | PGAM1 PSer118 | phosphorylation down-regulates ⊣ | PGAM1 | 12189148 | SIGNOR-91602 |
| PKN1 | phosphorylation up-regulates → | PGAM1 PSer23 | phosphorylation down-regulates ⊣ | PGAM1 | 12189148 | SIGNOR-91606 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer159 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-243199 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer163 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-249651 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer170 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-249671 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer159 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-248937 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer163 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-248938 |
| PKN1 | phosphorylation up-regulates → | MARCKS PSer170 | phosphorylation down-regulates ⊣ | MARCKS | 8557118 | SIGNOR-248939 |
| PKN1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 15791647 | SIGNOR-249277 |
| PKN1 | phosphorylation up-regulates → | PGM1 PThr467 | phosphorylation up-regulates → | PGM1 | 15378030 | SIGNOR-128722 |
| PKN1 | phosphorylation up-regulates → | FOXO1 PSer256 | phosphorylation down-regulates ⊣ | FOXO1 | 12560069 | SIGNOR-97882 |
| PKN1 | phosphorylation up-regulates → | PKN1 PSer374 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249021 |
| PKN1 | phosphorylation up-regulates → | PKN1 PThr531 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249020 |
| PKN1 | phosphorylation up-regulates → | PKN1 PThr64 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249019 |
| PKN1 | phosphorylation up-regulates → | ARHGEF2 PSer886 | phosphorylation down-regulates ⊣ | ARHGEF2 | 14970201 | SIGNOR-122191 |
| PKN1 | phosphorylation up-regulates → | FOXO PSer256 | phosphorylation down-regulates ⊣ | FOXO | 12560069 | SIGNOR-252968 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKN1 | phosphorylation → down-regulates activity | MEFV | SIGNOR-275462 |
| PKN1 | phosphorylation → down-regulates activity | MEFV | SIGNOR-275461 |
| PKN1 | phosphorylation → up-regulates | SNAI1 | SIGNOR-135609 |
| PKN1 | phosphorylation → down-regulates activity | EGFR | SIGNOR-174755 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-112549 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-135679 |
| PKN1 | phosphorylation → up-regulates | AR | SIGNOR-152762 |
| PKN1 | phosphorylation down-regulates | MAPT | SIGNOR-84958 |
| PKN1 | phosphorylation down-regulates | PGAM1 | SIGNOR-91602 |
| PKN1 | phosphorylation down-regulates | PGAM1 | SIGNOR-91606 |
| PKN1 | phosphorylation → down-regulates activity | MARCKS | SIGNOR-243199 |
| PKN1 | phosphorylation → down-regulates activity | MARCKS | SIGNOR-249651 |
| PKN1 | phosphorylation → down-regulates activity | MARCKS | SIGNOR-249671 |
| PKN1 | phosphorylation → unknown | MARCKS | SIGNOR-248937 |
| PKN1 | phosphorylation → unknown | MARCKS | SIGNOR-248938 |
| PKN1 | phosphorylation → unknown | MARCKS | SIGNOR-248939 |
| PKN1 | phosphorylation → unknown | CDC25C | SIGNOR-249277 |
| PKN1 | phosphorylation → up-regulates | PGM1 | SIGNOR-128722 |
| PKN1 | phosphorylation down-regulates | FOXO1 | SIGNOR-97882 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249021 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249020 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249019 |
| PKN1 | phosphorylation → up-regulates | MAPK14 | SIGNOR-152765 |
| PKN1 | phosphorylation down-regulates | ARHGEF2 | SIGNOR-122191 |
| PKN1 | phosphorylation → down-regulates activity | MRTFA | SIGNOR-280067 |
| PKN1 | phosphorylation → up-regulates | MAP3K20 | SIGNOR-152768 |
| PKN1 | phosphorylation down-regulates | FOXO | SIGNOR-252968 |
| PKN1 | phosphorylation down-regulates | PGAM | SIGNOR-270282 |