| Name | PKN1 |
| ID | Q16512 |
| Role | substrate |
| Enzymatic Domains |
REM-1 1 25-100 PROSITE-ProRule
REM-1 2 112-193 PROSITE-ProRule
REM-1 3 201-280 PROSITE-ProRule
C2 307-470 PROSITE-ProRule
Protein kinase 615-874 PROSITE-ProRule
AGC-kinase C-terminal 875-942 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | PKN1 | Ser537 | GTFSPGAsPGSEART | phosphorylation up-regulates activity | 31981797 | SIGNOR-276833 |
| PKN1 | PKN1 | Thr531 | PNATGTGtFSPGASP | phosphorylation up-regulates activity | 10467162 | SIGNOR-249020 |
| CDK1 | PKN1 | Ser562 | LGTDSDSsPQKSSRD | phosphorylation up-regulates activity | 31981797 | SIGNOR-276831 |
| PDPK1 | PKN1 | Thr774 | GYGDRTStFCGTPEF | phosphorylation up-regulates | 10753910 | SIGNOR-76640 |
| CDK1 | PKN1 | Ser916 | TGEAPTLsPPRDARP | phosphorylation up-regulates activity | 31981797 | SIGNOR-276832 |
| PKN1 | PKN1 | Ser374 | GLYSRSGsLSGRSSL | phosphorylation up-regulates activity | 10467162 | SIGNOR-249021 |
| CDK1 | PKN1 | Ser533 | ATGTGTFsPGASPGS | phosphorylation up-regulates activity | 31981797 | SIGNOR-276834 |
| PKN1 | PKN1 | Thr64 | ENLRRATtDLGRSLG | phosphorylation up-regulates activity | 10467162 | SIGNOR-249019 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | PKN1 PSer537 | phosphorylation up-regulates → | PKN1 | 31981797 | SIGNOR-276833 |
| PKN1 | phosphorylation up-regulates → | PKN1 PThr531 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249020 |
| CDK1 | phosphorylation up-regulates → | PKN1 PSer562 | phosphorylation up-regulates → | PKN1 | 31981797 | SIGNOR-276831 |
| PDPK1 | phosphorylation up-regulates → | PKN1 PThr774 | phosphorylation up-regulates → | PKN1 | 10753910 | SIGNOR-76640 |
| CDK1 | phosphorylation up-regulates → | PKN1 PSer916 | phosphorylation up-regulates → | PKN1 | 31981797 | SIGNOR-276832 |
| PKN1 | phosphorylation up-regulates → | PKN1 PSer374 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249021 |
| CDK1 | phosphorylation up-regulates → | PKN1 PSer533 | phosphorylation up-regulates → | PKN1 | 31981797 | SIGNOR-276834 |
| PKN1 | phosphorylation up-regulates → | PKN1 PThr64 | phosphorylation up-regulates → | PKN1 | 10467162 | SIGNOR-249019 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-276833 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249020 |
| CDK1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-276831 |
| PDPK1 | phosphorylation → up-regulates | PKN1 | SIGNOR-76640 |
| CDK1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-276832 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249021 |
| CDK1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-276834 |
| PKN1 | phosphorylation → up-regulates activity | PKN1 | SIGNOR-249019 |