| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | CRY1 | Ser71 | ANLRKLNsRLFVIRG | phosphorylation down-regulates quantity by destabilization | 19833968 | SIGNOR-268046 |
| AMPK | CRY1 | Ser71 | ANLRKLNsRLFVIRG | phosphorylation down-regulates | 21892142 | SIGNOR-216546 |
| PRKAA1 | CRY1 | Ser71 | ANLRKLNsRLFVIRG | phosphorylation down-regulates | 21892142 | SIGNOR-176472 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | CRY1 PSer71 | phosphorylation down-regulates ⊣ | CRY1 | 19833968 | SIGNOR-268046 |
| AMPK | phosphorylation up-regulates → | CRY1 PSer71 | phosphorylation down-regulates ⊣ | CRY1 | 21892142 | SIGNOR-216546 |
| PRKAA1 | phosphorylation up-regulates → | CRY1 PSer71 | phosphorylation down-regulates ⊣ | CRY1 | 21892142 | SIGNOR-176472 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation down-regulates quantity by destabilization | CRY1 | SIGNOR-268046 |
| AMPK | phosphorylation down-regulates | CRY1 | SIGNOR-216546 |
| PRKAA1 | phosphorylation down-regulates | CRY1 | SIGNOR-176472 |
