| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | DPYSL2 | Thr555 | DNIPRRTtQRIVAPP | phosphorylation unknown | 10818093 | SIGNOR-249042 |
| ROCK2 | DPYSL2 | Thr555 | DNIPRRTtQRIVAPP | phosphorylation up-regulates | 10818093 | SIGNOR-77543 |
| CDK5 | DPYSL2 | Ser522 | PASSAKTsPAKQQAP | phosphorylation down-regulates activity | 25040932 | SIGNOR-264838 |
| GSK3B | DPYSL2 | Thr514 | SVTPKTVtPASSAKT | phosphorylation down-regulates activity | 25040932 | SIGNOR-264840 |
| GSK3B | DPYSL2 | Thr514 | SVTPKTVtPASSAKT | phosphorylation down-regulates activity | 15652488 | SIGNOR-133255 |
| GSK3B | DPYSL2 | Ser518 | KTVTPASsAKTSPAK | phosphorylation down-regulates activity | 15652488 | SIGNOR-133251 |
| GSK3B | DPYSL2 | Thr509 | PVCEVSVtPKTVTPA | phosphorylation down-regulates activity | 25040932 | SIGNOR-264839 |
| TTBK1 | DPYSL2 | Thr514 | SVTPKTVtPASSAKT | phosphorylation up-regulates activity | 32019603 | SIGNOR-279313 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | phosphorylation up-regulates → | DPYSL2 PThr555 | phosphorylation down-regulates ⊣ | DPYSL2 | 10818093 | SIGNOR-249042 |
| ROCK2 | phosphorylation up-regulates → | DPYSL2 PThr555 | phosphorylation up-regulates → | DPYSL2 | 10818093 | SIGNOR-77543 |
| CDK5 | phosphorylation up-regulates → | DPYSL2 PSer522 | phosphorylation down-regulates ⊣ | DPYSL2 | 25040932 | SIGNOR-264838 |
| GSK3B | phosphorylation up-regulates → | DPYSL2 PThr514 | phosphorylation down-regulates ⊣ | DPYSL2 | 25040932 | SIGNOR-264840 |
| GSK3B | phosphorylation up-regulates → | DPYSL2 PThr514 | phosphorylation down-regulates ⊣ | DPYSL2 | 15652488 | SIGNOR-133255 |
| GSK3B | phosphorylation up-regulates → | DPYSL2 PSer518 | phosphorylation down-regulates ⊣ | DPYSL2 | 15652488 | SIGNOR-133251 |
| GSK3B | phosphorylation up-regulates → | DPYSL2 PThr509 | phosphorylation down-regulates ⊣ | DPYSL2 | 25040932 | SIGNOR-264839 |
| TTBK1 | phosphorylation up-regulates → | DPYSL2 PThr514 | phosphorylation up-regulates → | DPYSL2 | 32019603 | SIGNOR-279313 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK1 | phosphorylation → unknown | DPYSL2 | SIGNOR-249042 |
| ROCK2 | phosphorylation → up-regulates | DPYSL2 | SIGNOR-77543 |
| CDK5 | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-264838 |
| GSK3B | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-264840 |
| GSK3B | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-133255 |
| GSK3B | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-133251 |
| GSK3B | phosphorylation → down-regulates activity | DPYSL2 | SIGNOR-264839 |
| TTBK1 | phosphorylation → up-regulates activity | DPYSL2 | SIGNOR-279313 |
