| Name | NTRK2 |
| ID | Q16620 |
| Role | kinase |
| Enzymatic Domains |
LRRNT 32-61
LRRCT 148-196
Ig-like C2-type 1 197-282
Ig-like C2-type 2 295-365
Protein kinase 538-807 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK2 | FRS3 | Tyr417 | EPPRQLNyIQVELKG | phosphorylation up-regulates activity | 11432792 | SIGNOR-250202 |
| NTRK2 | FRS3 | Tyr455 | PARSSDSyAVIDLKK | phosphorylation up-regulates activity | 11432792 | SIGNOR-250203 |
| NTRK2 | PLCG1 | – | phosphorylation up-regulates activity | 20445044 | SIGNOR-279241 | |
| NTRK2 | KCNA3 | Tyr161 | PSFDAILyYYQSGGR | phosphorylation down-regulates | 19166614 | SIGNOR-183515 |
| NTRK2 | KCNA3 | Tyr162 | SFDAILYyYQSGGRI | phosphorylation down-regulates | 19166614 | SIGNOR-183519 |
| NTRK2 | KCNA3 | Tyr163 | FDAILYYyQSGGRIR | phosphorylation down-regulates | 19166614 | SIGNOR-183523 |
| NTRK2 | VAV2 | – | phosphorylation up-regulates activity | 21880903 | SIGNOR-280050 | |
| NTRK2 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | phosphorylation unknown | 10533983 | SIGNOR-250206 |
| NTRK2 | NTRK2 | Tyr707 | DVYSTDYyRVGGHTM | phosphorylation unknown | 10533983 | SIGNOR-250207 |
| NTRK2 | NTRK2 | Tyr516 | PVIENPQyFGITNSQ | phosphorylation up-regulates activity | 10533983 | SIGNOR-250204 |
| NTRK2 | NTRK2 | Tyr702 | FGMSRDVySTDYYRV | phosphorylation up-regulates activity | 10533983 | SIGNOR-250205 |
| NTRK2 | NTRK2 | Tyr817 | LAKASPVyLDILG | phosphorylation up-regulates activity | 10533983 | SIGNOR-250312 |
| NTRK2 | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273916 |
| NTRK2 | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273918 |
| NTRK2 | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273917 |
| NTRK2 | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273924 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK2 | phosphorylation up-regulates → | FRS3 PTyr417 | phosphorylation up-regulates → | FRS3 | 11432792 | SIGNOR-250202 |
| NTRK2 | phosphorylation up-regulates → | FRS3 PTyr455 | phosphorylation up-regulates → | FRS3 | 11432792 | SIGNOR-250203 |
| NTRK2 | phosphorylation up-regulates → | KCNA3 PTyr161 | phosphorylation down-regulates ⊣ | KCNA3 | 19166614 | SIGNOR-183515 |
| NTRK2 | phosphorylation up-regulates → | KCNA3 PTyr162 | phosphorylation down-regulates ⊣ | KCNA3 | 19166614 | SIGNOR-183519 |
| NTRK2 | phosphorylation up-regulates → | KCNA3 PTyr163 | phosphorylation down-regulates ⊣ | KCNA3 | 19166614 | SIGNOR-183523 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr706 | phosphorylation down-regulates ⊣ | NTRK2 | 10533983 | SIGNOR-250206 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr707 | phosphorylation down-regulates ⊣ | NTRK2 | 10533983 | SIGNOR-250207 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr516 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250204 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr702 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250205 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr817 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250312 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273916 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273918 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273917 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273924 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NTRK2 | phosphorylation → up-regulates activity | FRS3 | SIGNOR-250202 |
| NTRK2 | phosphorylation → up-regulates activity | FRS3 | SIGNOR-250203 |
| NTRK2 | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279241 |
| NTRK2 | phosphorylation down-regulates | KCNA3 | SIGNOR-183515 |
| NTRK2 | phosphorylation down-regulates | KCNA3 | SIGNOR-183519 |
| NTRK2 | phosphorylation down-regulates | KCNA3 | SIGNOR-183523 |
| NTRK2 | phosphorylation → up-regulates activity | VAV2 | SIGNOR-280050 |
| NTRK2 | phosphorylation → unknown | NTRK2 | SIGNOR-250206 |
| NTRK2 | phosphorylation → unknown | NTRK2 | SIGNOR-250207 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250204 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250205 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250312 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273916 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273918 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273917 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273924 |