| Name | NTRK2 |
| ID | Q16620 |
| Role | substrate |
| Enzymatic Domains |
LRRNT 32-61
LRRCT 148-196
Ig-like C2-type 1 197-282
Ig-like C2-type 2 295-365
Protein kinase 538-807 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | NTRK2 | – | dephosphorylation down-regulates activity | 28947394 | SIGNOR-277123 | |
| NTRK2 | NTRK2 | Tyr516 | PVIENPQyFGITNSQ | phosphorylation up-regulates activity | 10533983 | SIGNOR-250204 |
| NTRK2 | NTRK2 | Tyr702 | FGMSRDVySTDYYRV | phosphorylation up-regulates activity | 10533983 | SIGNOR-250205 |
| PTPN1 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | dephosphorylation down-regulates activity | 26214522 | SIGNOR-264554 |
| SRC | NTRK2 | – | phosphorylation up-regulates activity | 23115189 | SIGNOR-280130 | |
| NTRK2 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | phosphorylation unknown | 10533983 | SIGNOR-250206 |
| NTRK2 | NTRK2 | Tyr817 | LAKASPVyLDILG | phosphorylation up-regulates activity | 10533983 | SIGNOR-250312 |
| NTRK2 | NTRK2 | Tyr707 | DVYSTDYyRVGGHTM | phosphorylation unknown | 10533983 | SIGNOR-250207 |
| PTPN1 | NTRK2 | Tyr707 | DVYSTDYyRVGGHTM | dephosphorylation down-regulates activity | 26214522 | SIGNOR-264553 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr516 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250204 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr702 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250205 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NTRK2 PTyr706 | dephosphorylation up-regulates → | NTRK2 | 26214522 | SIGNOR-264554 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr706 | phosphorylation down-regulates ⊣ | NTRK2 | 10533983 | SIGNOR-250206 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr817 | phosphorylation up-regulates → | NTRK2 | 10533983 | SIGNOR-250312 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr707 | phosphorylation down-regulates ⊣ | NTRK2 | 10533983 | SIGNOR-250207 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NTRK2 PTyr707 | dephosphorylation up-regulates → | NTRK2 | 26214522 | SIGNOR-264553 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-277123 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250204 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250205 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-264554 |
| SRC | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-280130 |
| NTRK2 | phosphorylation → unknown | NTRK2 | SIGNOR-250206 |
| NTRK2 | phosphorylation → up-regulates activity | NTRK2 | SIGNOR-250312 |
| NTRK2 | phosphorylation → unknown | NTRK2 | SIGNOR-250207 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-264553 |