| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | dephosphorylation down-regulates activity | 26214522 | SIGNOR-264554 |
| NTRK2 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | phosphorylation unknown | 10533983 | SIGNOR-250206 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | NTRK2 PTyr706 | dephosphorylation up-regulates → | NTRK2 | 26214522 | SIGNOR-264554 |
| NTRK2 | phosphorylation up-regulates → | NTRK2 PTyr706 | phosphorylation down-regulates ⊣ | NTRK2 | 10533983 | SIGNOR-250206 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-264554 |
| NTRK2 | phosphorylation → unknown | NTRK2 | SIGNOR-250206 |
