Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PDK4	PDHA1	Ser300	SMSDPGVsYRTREEI	phosphorylation down-regulates	17474719	SIGNOR-154656
PDK4	PDHA1	Ser293	TYRYHGHsMSDPGVS	phosphorylation down-regulates	7782287	SIGNOR-33197
PDK4	PDHA1	Ser300	SMSDPGVsYRTREEI	phosphorylation down-regulates	7782287	SIGNOR-33201
PDK4	PDHA1	Ser232	NRYGMGTsVERAAAS	phosphorylation down-regulates activity	11485553	SIGNOR-109621
PDK4	PDHA1	Ser293	TYRYHGHsMSDPGVS	phosphorylation down-regulates activity	11485553	SIGNOR-109617
PDK4	PC	–		phosphorylation down-regulates activity	20638986	SIGNOR-278974
PDK4	PDHA2	Ser291	TYRYHGHsMSDPGVS	phosphorylation down-regulates	14966024	SIGNOR-121936

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PDK4	phosphorylation up-regulates →	PDHA1 PSer300	phosphorylation down-regulates ⊣	PDHA1	17474719	SIGNOR-154656
PDK4	phosphorylation up-regulates →	PDHA1 PSer293	phosphorylation down-regulates ⊣	PDHA1	7782287	SIGNOR-33197
PDK4	phosphorylation up-regulates →	PDHA1 PSer300	phosphorylation down-regulates ⊣	PDHA1	7782287	SIGNOR-33201
PDK4	phosphorylation up-regulates →	PDHA1 PSer232	phosphorylation down-regulates ⊣	PDHA1	11485553	SIGNOR-109621
PDK4	phosphorylation up-regulates →	PDHA1 PSer293	phosphorylation down-regulates ⊣	PDHA1	11485553	SIGNOR-109617
PDK4	phosphorylation up-regulates →	PDHA2 PSer291	phosphorylation down-regulates ⊣	PDHA2	14966024	SIGNOR-121936

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PDK4	phosphorylation down-regulates	PDHA1	SIGNOR-154656
PDK4	phosphorylation down-regulates	PDHA1	SIGNOR-33197
PDK4	phosphorylation down-regulates	PDHA1	SIGNOR-33201
PDK4	phosphorylation → down-regulates activity	PDHA1	SIGNOR-109621
PDK4	phosphorylation → down-regulates activity	PDHA1	SIGNOR-109617
PDK4	phosphorylation → down-regulates activity	PC	SIGNOR-278974
PDK4	phosphorylation down-regulates	PDHA2	SIGNOR-121936