Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK6	KALRN	–		phosphorylation up-regulates activity	22508986	SIGNOR-263094
MAPK6	TDP2	Ser60	EMERALNsYFEPPVE	phosphorylation up-regulates activity	26701725	SIGNOR-278245
MAPK6	TDP2	Ser60	EMERALNsYFEPPVE	phosphorylation up-regulates activity	26701725	SIGNOR-277188
MAPK6	MAPK6	Ser189 View in OncoXplorer	YSHKGHLsEGLVTKW	phosphorylation up-regulates	8621539	SIGNOR-40097
MAPK6	MAPKAPK5	Thr182	IDQGDLMtPQFTPYY	phosphorylation up-regulates activity	20734105	SIGNOR-279073
MAPK6	NCOA3	Ser857	PPYNRAVsLDSPVSV	phosphorylation up-regulates	22505454	SIGNOR-196957

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK6	phosphorylation up-regulates →	TDP2 PSer60	phosphorylation up-regulates →	TDP2	26701725	SIGNOR-278245
MAPK6	phosphorylation up-regulates →	TDP2 PSer60	phosphorylation up-regulates →	TDP2	26701725	SIGNOR-277188
MAPK6	phosphorylation up-regulates →	MAPK6 PSer189	phosphorylation up-regulates →	MAPK6	8621539	SIGNOR-40097
MAPK6	phosphorylation up-regulates →	MAPKAPK5 PThr182	phosphorylation up-regulates →	MAPKAPK5	20734105	SIGNOR-279073
MAPK6	phosphorylation up-regulates →	NCOA3 PSer857	phosphorylation up-regulates →	NCOA3	22505454	SIGNOR-196957

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK6	phosphorylation → up-regulates activity	KALRN	SIGNOR-263094
MAPK6	phosphorylation → up-regulates activity	TDP2	SIGNOR-278245
MAPK6	phosphorylation → up-regulates activity	TDP2	SIGNOR-277188
MAPK6	phosphorylation → up-regulates	MAPK6	SIGNOR-40097
MAPK6	phosphorylation → up-regulates activity	MAPKAPK5	SIGNOR-279073
MAPK6	phosphorylation → up-regulates	NCOA3	SIGNOR-196957