| Name | MAPK6 |
| ID | Q16659 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 20-316 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DUSP2 | MAPK6 | – | dephosphorylation down-regulates activity | 28252035 | SIGNOR-277069 | |
| CDC14A | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248830 |
| CDC14A | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248831 |
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248337 |
| CDK1 | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | phosphorylation up-regulates | 20236090 | SIGNOR-164487 |
| CDC14B | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248335 |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248334 |
| CDC14A | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates | 20236090 | SIGNOR-164416 |
| CDC14A | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248833 |
| CDC14A | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates | 20236090 | SIGNOR-164408 |
| CDC14B | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates | 20236090 | SIGNOR-164483 |
| MAPK6 | MAPK6 | Ser189 | YSHKGHLsEGLVTKW | phosphorylation up-regulates | 8621539 | SIGNOR-40097 |
| CDK1 | MAPK6 | Thr698 | KSIQATLtPSAMKSS | phosphorylation up-regulates | 20236090 | SIGNOR-164499 |
| CyclinB/CDK1 | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | phosphorylation up-regulates | 20236090 | SIGNOR-216801 |
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates | 20236090 | SIGNOR-164479 |
| CDC14A | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates | 20236090 | SIGNOR-164412 |
| CDC14A | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248832 |
| CyclinB/CDK1 | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | phosphorylation up-regulates | 20236090 | SIGNOR-216797 |
| CDK1 | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | phosphorylation up-regulates | 20236090 | SIGNOR-164495 |
| CDK1 | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | phosphorylation up-regulates | 20236090 | SIGNOR-164491 |
| CyclinB/CDK1 | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | phosphorylation up-regulates | 20236090 | SIGNOR-216805 |
| CDC14B | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248336 |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates | 20236090 | SIGNOR-164471 |
| CyclinB/CDK1 | MAPK6 | Thr698 | KSIQATLtPSAMKSS | phosphorylation up-regulates | 20236090 | SIGNOR-216809 |
| CDC14A | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates | 20236090 | SIGNOR-164404 |
| CDC14B | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates | 20236090 | SIGNOR-164475 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248830 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248831 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248337 |
| CDK1 | phosphorylation up-regulates → | MAPK6 PSer684 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164487 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248335 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248334 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164416 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248833 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164408 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164483 |
| MAPK6 | phosphorylation up-regulates → | MAPK6 PSer189 | phosphorylation up-regulates → | MAPK6 | 8621539 | SIGNOR-40097 |
| CDK1 | phosphorylation up-regulates → | MAPK6 PThr698 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164499 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PSer688 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216801 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164479 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164412 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248832 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PSer684 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216797 |
| CDK1 | phosphorylation up-regulates → | MAPK6 PSer705 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164495 |
| CDK1 | phosphorylation up-regulates → | MAPK6 PSer688 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164491 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PSer705 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216805 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248336 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164471 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PThr698 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216809 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164404 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164475 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DUSP2 | dephosphorylation → down-regulates activity | MAPK6 | SIGNOR-277069 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248830 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248831 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248337 |
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164487 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248335 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248334 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164416 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248833 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164408 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164483 |
| MAPK6 | phosphorylation → up-regulates | MAPK6 | SIGNOR-40097 |
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164499 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216801 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164479 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164412 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248832 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216797 |
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164495 |
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164491 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216805 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248336 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164471 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216809 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164404 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164475 |