| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | phosphorylation up-regulates | 20236090 | SIGNOR-164487 |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248334 |
| CyclinB/CDK1 | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | phosphorylation up-regulates | 20236090 | SIGNOR-216797 |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates | 20236090 | SIGNOR-164471 |
| CDC14A | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates | 20236090 | SIGNOR-164404 |
| CDC14A | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248830 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | MAPK6 PSer684 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164487 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248334 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PSer684 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216797 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164471 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164404 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248830 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164487 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248334 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216797 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164471 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164404 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248830 |
