| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248337 |
| CDC14A | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248833 |
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates | 20236090 | SIGNOR-164479 |
| CDC14A | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates | 20236090 | SIGNOR-164412 |
| CDK1 | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | phosphorylation up-regulates | 20236090 | SIGNOR-164495 |
| CyclinB/CDK1 | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | phosphorylation up-regulates | 20236090 | SIGNOR-216805 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248337 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248833 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164479 |
| CDC14A | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164412 |
| CDK1 | phosphorylation up-regulates → | MAPK6 PSer705 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164495 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MAPK6 PSer705 | phosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-216805 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248337 |
| CDC14A | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248833 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164479 |
| CDC14A | dephosphorylation down-regulates | MAPK6 | SIGNOR-164412 |
| CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-164495 |
| CyclinB/CDK1 | phosphorylation → up-regulates | MAPK6 | SIGNOR-216805 |
