| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273175 |
| RPS6KA5 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12773393 | SIGNOR-249213 |
| RPS6KA4 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12773393 | SIGNOR-249211 |
| CKM complex | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 18418385 | SIGNOR-273174 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 18418385 | SIGNOR-273175 |
| RPS6KA5 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249213 |
| RPS6KA4 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249211 |
| CKM complex | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 18418385 | SIGNOR-273174 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK8 | phosphorylation → down-regulates activity | H3-4 | SIGNOR-273175 |
| RPS6KA5 | phosphorylation → unknown | H3-4 | SIGNOR-249213 |
| RPS6KA4 | phosphorylation → unknown | H3-4 | SIGNOR-249211 |
| CKM complex | phosphorylation → down-regulates activity | H3-4 | SIGNOR-273174 |
