| Name | PTPRO |
| ID | Q16827 |
| Role | phosphatase |
| Enzymatic Domains |
Fibronectin type-III 1 50-124 PROSITE-ProRule
Fibronectin type-III 2 142-211 PROSITE-ProRule
Fibronectin type-III 3 246-306 PROSITE-ProRule
Fibronectin type-III 4 329-425 PROSITE-ProRule
Fibronectin type-III 5 435-531 PROSITE-ProRule
Fibronectin type-III 6 532-628 PROSITE-ProRule
Fibronectin type-III 7 631-724 PROSITE-ProRule
Fibronectin type-III 8 725-817 PROSITE-ProRule
Tyrosine-protein phosphatase 938-1195 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRO | ERBB2 | Tyr1248 | PTAENPEyLGLDVPV | dephosphorylation down-regulates quantity by destabilization | 27345410 | SIGNOR-276979 |
| PTPRO | LYN | – | dephosphorylation down-regulates activity | 20564182 | SIGNOR-277144 | |
| PTPRO | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25301722 | SIGNOR-277004 |
| PTPRO | STAT3 | Ser727 | NTIDLPMsPRTLDSL | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277061 |
| PTPRO | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 24708807 | SIGNOR-277062 |
| PTPRO | VCP | – | dephosphorylation down-regulates activity | 23533167 | SIGNOR-277063 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRO | dephosphorylation down-regulates ⊣ | ERBB2 PTyr1248 | dephosphorylation up-regulates → | ERBB2 | 27345410 | SIGNOR-276979 |
| PTPRO | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25301722 | SIGNOR-277004 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PSer727 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277061 |
| PTPRO | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 24708807 | SIGNOR-277062 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRO | dephosphorylation down-regulates quantity by destabilization | ERBB2 | SIGNOR-276979 |
| PTPRO | dephosphorylation → down-regulates activity | LYN | SIGNOR-277144 |
| PTPRO | dephosphorylation → down-regulates activity | SRC | SIGNOR-277004 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277061 |
| PTPRO | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277062 |
| PTPRO | dephosphorylation → down-regulates activity | VCP | SIGNOR-277063 |