| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | PFKFB3 | Ser461 | NPLMRRNsVTPLASP | phosphorylation up-regulates | 12065600 | SIGNOR-89760 |
| MAPK12 | PFKFB3 | Ser467 | NSVTPLAsPEPTKKP | phosphorylation up-regulates quantity | 32580961 | SIGNOR-279539 |
| AMPK | PFKFB3 | Ser461 | NPLMRRNsVTPLASP | phosphorylation up-regulates | 12065600 | SIGNOR-216639 |
| PIM2 | PFKFB3 | Ser478 | TKKPRINsFEEHVAS | phosphorylation up-regulates quantity by stabilization | 33931981 | SIGNOR-277554 |
| AKT | PFKFB3 | Ser461 | NPLMRRNsVTPLASP | phosphorylation up-regulates | 15896703 | SIGNOR-137241 |
| AKT1 | PFKFB3 | Ser461 | NPLMRRNsVTPLASP | phosphorylation up-regulates | 15896703 | SIGNOR-252477 |
| IKBKB | PFKFB3 | Ser269 | QGRIGGDsGLSSRGK | phosphorylation down-regulates activity | 27585591 | SIGNOR-277278 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | PFKFB3 PSer461 | phosphorylation up-regulates → | PFKFB3 | 12065600 | SIGNOR-89760 |
| MAPK12 | phosphorylation up-regulates → | PFKFB3 PSer467 | phosphorylation up-regulates → | PFKFB3 | 32580961 | SIGNOR-279539 |
| AMPK | phosphorylation up-regulates → | PFKFB3 PSer461 | phosphorylation up-regulates → | PFKFB3 | 12065600 | SIGNOR-216639 |
| PIM2 | phosphorylation up-regulates → | PFKFB3 PSer478 | phosphorylation up-regulates → | PFKFB3 | 33931981 | SIGNOR-277554 |
| AKT | phosphorylation up-regulates → | PFKFB3 PSer461 | phosphorylation up-regulates → | PFKFB3 | 15896703 | SIGNOR-137241 |
| AKT1 | phosphorylation up-regulates → | PFKFB3 PSer461 | phosphorylation up-regulates → | PFKFB3 | 15896703 | SIGNOR-252477 |
| IKBKB | phosphorylation up-regulates → | PFKFB3 PSer269 | phosphorylation down-regulates ⊣ | PFKFB3 | 27585591 | SIGNOR-277278 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation → up-regulates | PFKFB3 | SIGNOR-89760 |
| MAPK12 | phosphorylation → up-regulates quantity | PFKFB3 | SIGNOR-279539 |
| AMPK | phosphorylation → up-regulates | PFKFB3 | SIGNOR-216639 |
| PIM2 | phosphorylation → up-regulates quantity by stabilization | PFKFB3 | SIGNOR-277554 |
| AKT | phosphorylation → up-regulates | PFKFB3 | SIGNOR-137241 |
| AKT1 | phosphorylation → up-regulates | PFKFB3 | SIGNOR-252477 |
| IKBKB | phosphorylation → down-regulates activity | PFKFB3 | SIGNOR-277278 |
