Entity Details

Name LRRK1
ID Q38SD2
Role kinase
Enzymatic Domains
Roc 632-826
PROSITE-ProRule
COR 844-1036

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Protein kinase 1242-1525
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LRRK1CLIP1Thr1430EMFGHWAtNCNDDETphosphorylation
up-regulates activity		25413345SIGNOR-275469
LRRK1RAB7ASer72AGQERFQsLGVAFYRphosphorylation
up-regulates activity		33459343SIGNOR-278212
LRRK1RAC1–phosphorylation
up-regulates activity		27600824SIGNOR-279626
LRRK1CDK5RAP2Ser140SLAEAGGsEIQRVKEphosphorylation
up-regulates activity		26192437SIGNOR-275468
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LRRK1phosphorylation
up-regulates
→
CLIP1
PThr1430		phosphorylation
up-regulates
→		CLIP125413345SIGNOR-275469
LRRK1phosphorylation
up-regulates
→
RAB7A
PSer72		phosphorylation
up-regulates
→		RAB7A33459343SIGNOR-278212
LRRK1phosphorylation
up-regulates
→
CDK5RAP2
PSer140		phosphorylation
up-regulates
→		CDK5RAP226192437SIGNOR-275468
Regulator Mechanism/Effect Target SIGNOR-ID
LRRK1phosphorylation
→
up-regulates activity 		CLIP1SIGNOR-275469
LRRK1phosphorylation
→
up-regulates activity 		RAB7ASIGNOR-278212
LRRK1phosphorylation
→
up-regulates activity 		RAC1SIGNOR-279626
LRRK1phosphorylation
→
up-regulates activity 		CDK5RAP2SIGNOR-275468