Entity Details

Name LRRK1
ID Q38SD2
Role substrate
Enzymatic Domains
Roc 632-826
PROSITE-ProRule
COR 844-1036

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Protein kinase 1242-1525
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCALRRK1Ser1074GNQRNRCsTFRVKRNphosphorylation
up-regulates activity		36040231SIGNOR-276867
PRKCALRRK1Thr1075NQRNRCStFRVKRNQphosphorylation
up-regulates activity		36040231SIGNOR-276865
EGFRLRRK1Tyr971TQQTEEQyFQFLAKFphosphorylation
down-regulates activity		22337768SIGNOR-262856
PRKCALRRK1Ser1064NRKVTIYsFTGNQRNphosphorylation
up-regulates activity		36040231SIGNOR-276866
PLK1LRRK1Ser1817GDSIADVsIMYSEELphosphorylation
up-regulates activity		26192437SIGNOR-275467
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCAphosphorylation
up-regulates
→
LRRK1
PSer1074		phosphorylation
up-regulates
→		LRRK136040231SIGNOR-276867
PRKCAphosphorylation
up-regulates
→
LRRK1
PThr1075		phosphorylation
up-regulates
→		LRRK136040231SIGNOR-276865
EGFRphosphorylation
up-regulates
→
LRRK1
PTyr971		phosphorylation
down-regulates
⊣		LRRK122337768SIGNOR-262856
PRKCAphosphorylation
up-regulates
→
LRRK1
PSer1064		phosphorylation
up-regulates
→		LRRK136040231SIGNOR-276866
PLK1phosphorylation
up-regulates
→
LRRK1
PSer1817		phosphorylation
up-regulates
→		LRRK126192437SIGNOR-275467
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCAphosphorylation
→
up-regulates activity 		LRRK1SIGNOR-276867
PRKCAphosphorylation
→
up-regulates activity 		LRRK1SIGNOR-276865
EGFRphosphorylation
→
down-regulates activity 		LRRK1SIGNOR-262856
PRKCAphosphorylation
→
up-regulates activity 		LRRK1SIGNOR-276866
PLK1phosphorylation
→
up-regulates activity 		LRRK1SIGNOR-275467