| Name | PDCD4 |
| ID | Q53EL6 |
| Role | substrate |
| Enzymatic Domains |
MI 1 163-284 PROSITE-ProRule
MI 2 326-449 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-252496 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150144 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160989 |
| AKT1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-252505 |
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160982 |
| AKT1 | PDCD4 | Ser457 | RGRKRFVsEGDGGRL | phosphorylation down-regulates | 16357133 | SIGNOR-252488 |
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150140 |
| RPS6KB2 | PDCD4 | – | phosphorylation down-regulates | 18296647 | SIGNOR-160992 | |
| AKT | PDCD4 | Ser457 | RGRKRFVsEGDGGRL | phosphorylation down-regulates | 16357133 | SIGNOR-143098 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-252496 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160989 |
| AKT1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-252505 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160982 |
| AKT1 | phosphorylation up-regulates → | PDCD4 PSer457 | phosphorylation down-regulates ⊣ | PDCD4 | 16357133 | SIGNOR-252488 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150140 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer457 | phosphorylation down-regulates ⊣ | PDCD4 | 16357133 | SIGNOR-143098 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation down-regulates | PDCD4 | SIGNOR-252496 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-160989 |
| AKT1 | phosphorylation down-regulates | PDCD4 | SIGNOR-252505 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-160982 |
| AKT1 | phosphorylation down-regulates | PDCD4 | SIGNOR-252488 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-150140 |
| RPS6KB2 | phosphorylation down-regulates | PDCD4 | SIGNOR-160992 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-143098 |