Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT1	PDCD4	Ser457 View in OncoXplorer	RGRKRFVsEGDGGRL	phosphorylation down-regulates	16357133	SIGNOR-252488
AKT	PDCD4	Ser457 View in OncoXplorer	RGRKRFVsEGDGGRL	phosphorylation down-regulates	16357133	SIGNOR-143098

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT1	phosphorylation up-regulates →	PDCD4 PSer457	phosphorylation down-regulates ⊣	PDCD4	16357133	SIGNOR-252488
AKT	phosphorylation up-regulates →	PDCD4 PSer457	phosphorylation down-regulates ⊣	PDCD4	16357133	SIGNOR-143098

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT1	phosphorylation down-regulates	PDCD4	SIGNOR-252488
AKT	phosphorylation down-regulates	PDCD4	SIGNOR-143098