| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150140 |
| AKT1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-252496 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 17053147 | SIGNOR-150144 |
| RPS6KB1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160989 |
| AKT1 | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-252505 |
| AKT | PDCD4 | Ser67 | KRRLRKNsSRDSGRG | phosphorylation down-regulates | 18296647 | SIGNOR-160982 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150140 |
| AKT1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-252496 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 17053147 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160989 |
| AKT1 | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-252505 |
| AKT | phosphorylation up-regulates → | PDCD4 PSer67 | phosphorylation down-regulates ⊣ | PDCD4 | 18296647 | SIGNOR-160982 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-150140 |
| AKT1 | phosphorylation down-regulates | PDCD4 | SIGNOR-252496 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-150144 |
| RPS6KB1 | phosphorylation down-regulates | PDCD4 | SIGNOR-160989 |
| AKT1 | phosphorylation down-regulates | PDCD4 | SIGNOR-252505 |
| AKT | phosphorylation down-regulates | PDCD4 | SIGNOR-160982 |
