| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | CRTC2 | Ser170 | PSALNRTsSDSALHT | phosphorylation down-regulates | 21892142 | SIGNOR-216541 |
| PRKAA1 | CRTC2 | Ser170 | PSALNRTsSDSALHT | phosphorylation down-regulates | 21892142 | SIGNOR-176426 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | CRTC2 PSer170 | phosphorylation down-regulates ⊣ | CRTC2 | 21892142 | SIGNOR-216541 |
| PRKAA1 | phosphorylation up-regulates → | CRTC2 PSer170 | phosphorylation down-regulates ⊣ | CRTC2 | 21892142 | SIGNOR-176426 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation![]() down-regulates | CRTC2 | SIGNOR-216541 |
| PRKAA1 | phosphorylation![]() down-regulates | CRTC2 | SIGNOR-176426 |