| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 16148943 | SIGNOR-140238 |
| PRKAA2 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 16308421 | SIGNOR-142211 |
| AMPK | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 20577053 | SIGNOR-216576 |
| SIK1 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 16817901 | SIGNOR-147707 |
| PRKAA2 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 20577053 | SIGNOR-166365 |
| SIK2 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 20577053 | SIGNOR-166372 |
| SIK2 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates | 16308421 | SIGNOR-142218 |
| SIK3 | CRTC2 | Ser171 | SALNRTSsDSALHTS | phosphorylation down-regulates activity | 16306228 | SIGNOR-249172 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16148943 | SIGNOR-140238 |
| PRKAA2 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16308421 | SIGNOR-142211 |
| AMPK | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 20577053 | SIGNOR-216576 |
| SIK1 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16817901 | SIGNOR-147707 |
| PRKAA2 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 20577053 | SIGNOR-166365 |
| SIK2 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 20577053 | SIGNOR-166372 |
| SIK2 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16308421 | SIGNOR-142218 |
| SIK3 | phosphorylation up-regulates → | CRTC2 PSer171 | phosphorylation down-regulates ⊣ | CRTC2 | 16306228 | SIGNOR-249172 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA2 | phosphorylation down-regulates | CRTC2 | SIGNOR-140238 |
| PRKAA2 | phosphorylation down-regulates | CRTC2 | SIGNOR-142211 |
| AMPK | phosphorylation down-regulates | CRTC2 | SIGNOR-216576 |
| SIK1 | phosphorylation down-regulates | CRTC2 | SIGNOR-147707 |
| PRKAA2 | phosphorylation down-regulates | CRTC2 | SIGNOR-166365 |
| SIK2 | phosphorylation down-regulates | CRTC2 | SIGNOR-166372 |
| SIK2 | phosphorylation down-regulates | CRTC2 | SIGNOR-142218 |
| SIK3 | phosphorylation → down-regulates activity | CRTC2 | SIGNOR-249172 |
